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    Hemodynamic effects of atrial natriuretic peptide in ischemia-reperfusion injury that occurs after exercise
    (Tubitak Scientific & Technological Research Council Turkey, 2015) Vardar, Selma Arzu; Palabiyik, Orkide; Topuz, Ruhan Deniz; Gurel, Elif Ezgi; Caliskan, Semra; Topcu Ozen, Serap; Sut, Necdet
    Background/aim: Atrial natriuretic peptide (ANP) is known as a protective agent against ischemia-reperfusion injury for cardiomyocytes. We compared the hemodynamic effects of ANP and isatin, which is known as an ANP receptor blocker, in ischemia followed by reperfusion in exercised rat hearts with nonexercised ones. Materials and methods: Isolated hearts were perfused in 4 exercised (E) groups after a running protocol for 5 days and 4 nonexercised (NE) groups. In the first protocol, ANP was added to the perfusion solution before ischemia in an E and NE group. In the second protocol, different doses of isatin (0.1, 10, 100 mu M/L) were added to the perfusion solution before ANP in 3 E and 3 NE groups. Left ventricular developed pressure (LVDP) and maximum and minimum rates of change in left ventricular pressure (dP/dtmax and dP/dtmin) were recorded. Results: Higher LVDP and dP/dtmin values were observed in the E group than the NE group following addition of ANP before ischemia. Values of dP/dtmax were higher in the E group at the first minute of reperfusion period. Hemodynamic difference was not observed between groups given the same amount of isatin before ANP. Conclusion: This study indicated that higher ANP concentrations before ischemia were more effective on the left ventricle contractility and relaxation functions in the hearts that were exposed to exercise.
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    Pb and Cd Contamination in Agricultural Crops of Corlu: The Effects of Transportation and Industry
    (Destech Publications, Inc, 2008) Sahmurova, Aida; Caliskan, Semra; Babaoglu, Mehmet
    Tissue cadmium (Cd) and lead (Pb) concentrations of agricultural crops grown in and around Corlu district in the vicinity of an industrial zone and main highway leading from Istanbul to Europe were investigated. Plant samples were taken from 11 locations and were analysed by ICP (inductively Coupled Plasma Spectrometry). The concentrations of lead were between 0.221-0.383 mg kg(-1) in wheat, 0.526-0.754 mg kg(-1) in sunflower, 5.865-0.223 mg kg(-1) in corn, 1.469-3.517 mg kg(-1) in lettuce, 2.013-2.323 mg kg(-1) in parsley, 0.587 mg kg(-1) in peppers, 2.672 mg kg(-1) in potatoes and 1.367-4.586 mg kg-1 in onions. The samples contained cadmium concentrations between 0.026-0.048 ppm in wheat, 0.072-0.093 ppm in sunflower, 0.452-0.025 ppm in corn, 0.501-0.621 ppm in lettuce, 0.209-0.396 ppm in parsley, 0.014 ppm in pepper, 0.462 ppm in potato and 0.213-0.513 in onion. Accordingly, heavy metal pollution was detected in the plants growing in and in the surroundings of Corlu according to the Turkish Food Codex requiring measures against the pollutant sources.