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Öğe Detection of sacroillitis and spinal inflammation on colour and duplex doppler sonography in patients with ankylosing spondylitis(B M J Publishing Group, 2006) Pamuk, O. N.; Unlu, E.; Cakir, N.[Abstract Not Available]Öğe The development of trigeminal neuralgia related to auricular chondritis in a patient with rheumatoid arthritis - relapsing polychondritis and its treatment with etanercept. Description of the first case(Clinical & Exper Rheumatology, 2009) Pamuk, Oe N.; Harmandar, F.; Cakir, N.Cranial neuropathy is an uncommon manifestation of relapsing polychondritis (RPC). Optic neuropathy is the most common type of cranial nerve involvement in RPC. Until now, trigeminal neuralgia (TN) has been reported with different rheumatic diseases, however; there is no reported case of TN associated with RPC. We here present a case of RPC with TN. A 57 year-old female patient previously diagnosed with rheumatoid arthritis (RA) and RPC presented its with polyarthritis, auricular and nasal chondritis, and TN. Cranial MRI and MRI angiography of the brain did not show any pathology. The patient partially responded to RA therapy; and carbamazepine and etanercept were administered. RA-related Joint findings, her chondritis and TN symptoms improved completely with etanercept. We presume that the TN was caused by compression of the trigeminal nerve from inflammation or ischemia secondary to vasculitis.Öğe The frequency of smoking in fibromyalgia patients and its associaton with symptoms(B M J Publishing Group, 2006) Pamuk, O. N.; Cakir, N.[Abstract Not Available]Öğe Giant cell arteritis and polymyalgia rheumatica in northwestern Turkey: Clinical features and epidemiological data(Clinical & Exper Rheumatology, 2009) Pamuk, O. N.; Donmez, S.; Karahan, B.; Pamuk, G. E.; Cakir, N.Objective. In this study, we evaluated clinical and epidemiologic features of our giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) patients. Methods. Me retrospectively recorded down the general features of patients with GCA and PMR diagnosed at our center within the last 6 years. The incidence rates per 100000 aged. >= 50 were calculated. In addition, we reported the frequencies of GCA/PMR in our previous epidemiologic study. Results. Nineteen patients were diagnosed with GCA (10F, 9M) and 53 with isolated PMR (39F 14M). The annual incidence for GCA in subjects >= 50 years old was 1.13/100000, and for PMR it was 3.15/100000. The incidence of GCA and PMR in females were, respectively, 1.14/100000 and 4.48/100000. In males, the incidences of GCA and PMR were, respectively, calculated as 1.1/100000 and 1.72/100000. In our population-based study, the prevalences of GCA and PMR (>= 50 ages) were estimated as 20/100000. Fourteen (73.7%) GCA patients had symptoms of PMR. Two patients had developed unilateral and one patient bilateral permanent visual loss. Initial ESR was lower than 40 mm/hr in one GCA patient (5.3%) and in 6 PMR patients (11.3%). The median duration of follow-up(l) was 16 months in GCA; and 8 months in PMR patients. One patient with PMR and another patient with GCA had lung cancer. One PMR patient had myelodysplastic syndrome. During follow-up, 4 patients with GCA died. Conclusions. Me detected a lower frequency GCA/PMR in our center in northwestern Turkey than in Scandinavian and southern European countries.Öğe Impact of rheumatoid arthritis in Turkey: a questionnaire study(Clinical & Exper Rheumatology, 2014) Direskeneli, H.; Akkoc, N.; Bes, C.; Cakir, N.; Cefle, A.; Cobankara, V.; Dalkilic, E.Objective Unmet needs of rheumatoid arthritis (RA) patients regarding physician/patient communication, treatment preferences and quality of life issues were investigated in a Turkish survey study. Methods The study was conducted with the contribution of 33 rheumatologists, and included 519 RA patients. The study population included patients who had been on biologic therapy for >6 months and were still receiving biologic therapy (BT group), and those who were biologic naive, but found eligible for biologic treatment (NBT group). Of the RA patients, 35.5% initially had a visit to an internal disease specialist, 25.5% to a physical therapy and rehabilitation specialist, and 12.2% to a rheumatology specialist for their RA complaints. The diagnosis of RA was made by a rheumatologist in 48.2% of patients. Results The majority of RA patients (86.3%) visit their doctor within 15-week intervals. Most of the physician-patient communication focused on disease symptoms (99.0%) and impact of the disease on quality of life (61.8%). The proportion of RA patients who perceived their health status as good/very good/excellent was higher in the BT group than in the NBT group (74.3% vs. 51.5%, p<0.001). However, of those RA patients in the NBT group, only 24.8% have been recommended to start a biologic treatment by their doctors. With respect to dose frequency options, once-monthly injections were preferred (80%) to a bi-weekly injection schedule (8%). Conclusion In conclusion, RA patients receiving biologic therapy reported higher rates of improved symptoms and better quality of life and seemed to be more satisfied with their treatment in our study.Öğe Increased frequencies of hysterectomy and early menopause in fibromiyalgia patients and associated factors(B M J Publishing Group, 2006) Pamuk, O. N.; Cakir, N.[Abstract Not Available]Öğe An increased frequency of gallbladder stones in rheumatoid arthritis patients.: Factors related to gallbladder stone formation(Clinical & Exper Rheumatology, 2006) Pamuk, O. N.; Umit, H.; Unlu, E.; Koker, I. H.; Cakir, N.Objective. In this study, we determined the frequency of gallbladder stone (GBS) in rheumatoid arthritis (RA) patients and evaluated factors which could affect the formation of GBS such as lipids and the GB motilities of the patients. Methods. One hundred and thirteen RA patients (92F, 21M, mean disease duration: 8.9 years) and 117 healthy controls (94F, 23M) were included. In all RA patients, the clinical findings were recorded down; biochemical parameters and body mass index (BMI) were determined; and, abdominal ultrasonography was performed. In addition, 16 RA patients and 20 controls who were age-matched were randomly chosen for GB emptying monitored by ultrasound at 30-minute intervals for 2 hours after a mixed meal. Fasting volume (FV), residual volume (RV) and ejection fraction (EF) for all GBs were assessed. Results. There was a tendency towards a higher frequency of GBS including cholecystectomy (11 GBS, 11 cholecystectomy, 19.5%) in RA patients when compared to controls (8 GBS, 5 cholecystectomy, 11.1%) (p = 0.08). The frequency of GBS plus cholecyctectomy in female RA patients (22.8%) was significantly higher than the control group (11.7%, p = 0.044). Logistic regression analysis showed that only older age was significantly associated with the presence of GBS in RA (OR:1.05, p = 0.048). There was no difference between the 2 groups in FV (p > 0.05). RV PRV and EF were significantly higher in RA patients than in the control group (p < 0.05). Conclusions. We diagnosed a higher frequency of GBS in female RA patients when compared to controls. Impaired GB motility in RA patients might contribute to an increased incidence of GBS development.Öğe Increased frequency of gastrointestinal symptoms in fibromiyalgia patients and associated factors(B M J Publishing Group, 2007) Pamuk, Oe. N.; Doenmez, S.; Yesil, Y.; Harmandar, O.; Cakir, N.[Abstract Not Available]Öğe A low prevalance of purified protein derivative test positivity in Turkish patients with rheumatoid arthritis.: Association with clinical features and HRCT findings(Clinical & Exper Rheumatology, 2007) Koker, I. H.; Pamuk, O. N.; Karlikaya, C.; Tuncbilek, N.; Cakir, N.Objectives In this study, we aimed to evaluate the frequency of purified protein derivative (PPD) skin test positivity and associated clinical features in RA patients. Materials and methods We included 94 (80 F, 14 M, mean age: 55.8) consecutive RA patients with a disease duration of 8.7 years. PPD test was performed in all RA patients; clinical features were recorded down; chest x-ray, pulmonary function tests and HRCT were available in all cases. As the control group, we included data of 21 SLE, 44 AS, 27 OA, 16 gouty arthritis and 18 vasculitis patients. Results The frequencies of PPD positivity in RA (29.8%) and SLE (19%) patients were lower than in patients with AS (65.9%), gouty arthritis (68.8%) and OA (63%) (all p values < 0.01). PPD-positive RA patients were more frequently smokers (p = 0.005) and had a higher rate of RF seropositivity (p = 0.04) than PPD-negatives. PPD was less frequently positive in erosive RA disease (p = 0.033). Chest x-rays and HRCT abnormalities were detected in 41.8% and 62.7% of RA patients, respectively. Frequencies of chest x-ray and HRCT abnormalities in PPD-positive and PPD-negative patients were not difterent from each other (p > 0.05). Conclusion In our country in which tuberculosis is relatively frequent -contrary to the situation in AS patients- we observed a lower frequency of PPD positivity in RA and SLE patients compared to patients with other rheumatic diseases. We did not find any relationship between PPD positivity and the frequency of chest x-ray, HRCT abnormalities.Öğe The results of purified protein derivative test in ankylosing spondylitis patients(B M J Publishing Group, 2007) Pamuk, Oe. N.; Yesil, Y.; Donmez, S.; Uenlue, E.; Cakir, N.[Abstract Not Available]
