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Öğe Effect of aqueous extract and anthocyanins of calyces of Hibiscus sabdariffa (Malvaceae) in rats with adenine-induced chronic kidney disease(Wiley, 2017) Ali, Badreldin H.; Cahlikova, Lucie; Opletal, Lubomir; Karaca, Turan; Manoj, Priyadarsini; Ramkumar, Aishwarya; Al Suleimani, Yousuf M.ObjectivesThe aim of this work was to assess the possible beneficial effects of aqueous extracts of Hibiscus sabdariffa L. calyces and anthocyanins isolated therefrom in an adenine-induced chronic kidney disease (CKD) model. MethodsRats were orally given, for 28 consecutive days, either adenine alone or together with either aqueous extract of H. sabdariffa calyces (5 and 10%) or anthocyanins (50, 100 and 200 mg/kg of anthocyanin concentrate). For comparative purposes, two groups of rats were given lisinopril (10 mg/kg). Key findingsWhen either H. sabdariffa aqueous extract or the anthocyanins isolated from it was administered along with adenine, the adverse effects of adenine-induced CKD were significantly lessened, mostly in a dose-dependent manner. The positive effects were similar to those obtained by administration of lisinopril. ConclusionsThe results obtained show that both H. sabdariffa and its anthocyanins could be considered as possible promising safe dietary agents that could be used to attenuate the progression of human CKD. This could have added significance as H. sabdariffa tea is widely consumed in many parts of Africa and Asia and is thus readily available.Öğe Effect of Aqueous Extract and Anthocyanins of Calyces of Hibiscus sabdariffa L. (Malvaceae) in Rats with Adenine - Induced Chronic Kidney Disease(Federation Amer Soc Exp Biol, 2017) Ali, Badreldin H.; Cahlikova, Lucie; Opletal, Lubomir; Karaca, Turan; Al Suleimani, Yousuf; Al Za'abi, Mohammed H.; Nemmar, Abderrahim[Abstract Not Available]Öğe Preparation and Validated Analysis of Anthocyanin Concentrate from the Calyces of Hibiscus sabdariffa(Natural Products Inc, 2017) Opletal, Lubomir; Chocholousova-Havlikova, Lucie; Siatka, Tomas; Cahlikova, Lucie; Locarek, Miroslav; Ali, Badreldin H.; Manoj, PriyadarshiniExtracts of Hibiscus sabdarffa calyces have been shown to have various medicinal properties, some of which have been reported to be due to anthocyanins present in the calyces. To study whether these claims are valid, it is necessary to produce an extract with a high anthocyanin content and to have available a method to identify and quantify the individual compounds in the product. A method of extraction and purification has been developed based on a polyamide column chromatographic purification step. Using this method, anthocyanin concentrates were produced containing from 57 to 64% of delphinidin-3-sambubioside plus cyanidin-3-sambubioside. A rapid, efficient and validated HPLC analytical method was developed and used for the analysis of the anthocyanin concentrate.