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    Value of technetium-99m diethyltriamine pentaaceticacid radioaerosol inhalation lung scintigraphy for the stage of amiodarone-induced pulmonary toxicity
    (Elsevier Ireland Ltd, 2004) Durmus-Altun, G; Altun, A; Salihoglu, YS; Altaner, S; Berkada, S; Ozbay, G
    Background: Amiodarone is a potent antiarrhythmic agent that is limited in clinical use by its adverse effects, including potentially life threatening amiodarone-induced pulmonary toxicity (AIPT). The alteration of technetium-99m diethyltriaminepentaaceticacid (Tc-99m DTPA) radioaerosol lung clearance in AIPT was experimentally investigated. Methods: Eighteen white New Zealand rabbits (initial weight 4.1 +/- 0.2 kg) were divided into two groups. AIPT group (n = 13) was administered amiodarone (20 mg/kg BW) ip as a 5% aqueous solution for 6 week. The controls (n = 5) were administered the same amount of 0.9% saline ip. Four rabbits of AIPT group died due to AIPT. The reminders of AIPT group (n = 9) and controls underwent Tc-99rn DTPA radioaerosol lung scintigraphy at the end of the treatment period. AIPT group was divided into two subgroups according to histopathologic evaluation. AIPT-I had interstitial pneumonitis (n = 4) and AIPT-II had interstitial pneumonitis with fibrosis (n=5). Results: The mean T-1/2 values of in control, AIPT-I, and AIPT-II groups were found 54 +/- 4.4, 39.2 +/- 11.7 and 114.6 +/- 16.7 min, respectively. The mean T-1/2 values of Tc-99m DTPA significantly differ than other groups (chi(2) = 11.78, P=0.02). The significantly increased T-1/2 values was noted in AIPT-II group when compared with control (P=0.001). In contrast, AIPT-I group has significantly lower T-1/2 values than control group (P=0.03). Conclusion: We suggested that Tc-99m DTPA radioaerosol inhalation lung scintigraphy provides an accurate evaluation about stage of lung toxicity and therefore may be a useful tool for the monitoring of AIPT. (C) 2003 Elsevier Ireland Ltd. All rights reserved.