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    Effects of Hyalobarrier gel and Seprafilm in preventing peritendinous adhesions following crush-type injury in a rat model
    (Turkish Assoc Trauma Emergency Surgery, 2019) Sikar, Emel Yurdakul; Sikar, Hasan Ediz; Top, Husamettin; Aygit, Ahmet Cemal
    BACKGROUND: In the present study, the aim was to evaluate the effects of Hyalobarrier gel (Anika Therapeutics S.r.l., Abano Terme, Italy) and Seprafilm adhesion barrier (Genzyme Corporation, Cambridge, MA, USA) in the prevention of peritendinous adhesions following a crush-type injury. METHODS: Twenty five female Wistar Albino rats, weighing 230 to 270 g and 7 to 9 months of age were randomized into 5 groups. Group 1 was the control group, Group 2 comprised the Hyalobarrier gel group, Group 3 was made up of the Seprafilm-treated subjects, Group 4 was the tendon repair and Hyalobarrier gel group, and Group 5 was the tendon repair and Seprafilm group. Two gastrocnemius muscle tendons of each animal, a total of 50 tendons, were used. The animals were sacrificed with the administration of a high dose of anesthetic on postoperative day 40. Macroscopic evaluation of adhesions was classified by 2 blinded researchers according to Tang's adhesion grading system. The number of fibroblasts and the density and formation of collagen fibers were noted for histopathological examination. RESULTS: None of the subjects in Group 2 was determined to have a severe adhesion, and moderate or severe adhesions were detected in Groups 3, 4, and 5. There was no statistically significant difference between Group 2 and the control group (p= 0.737). Groups 3, 4, and 5 demonstrated fewer adhesions than Groups 1 and 2 (p<0.05). Groups 4 and 5 had fewer adhesions than Groups 2 and 3 (p< 0.05). There was no statistically significant difference between Groups 4 and 3 (p= 0.342). The histopathological findings were consistent with the macroscopic findings. CONCLUSION: Seprafilm was found to be effective in the prevention of peritendinous adhesions following a crush-type injury with or without repair of the tendon fibers. In contrast, Hyalobarrier gel was found to be effective only following repair of the tendon fibers.
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    Fucoidin, a neutrophil rolling inhibitor, reduces damage in a rat electrical burn injury model
    (Elsevier Sci Ltd, 2011) Benlier, Erol; Eskiocak, Sevgi; Puyan, Fulya Oz; Kandulu, Huseyin; Unal, Yasin; Top, Husamettin; Aygit, Ahmet Cemal
    Background: Electrical injuries induce progressive tissue loss caused by free oxygen radicals released from neutrophil aggregates. Fucoidin, a potent inhibitor of L-selectin function, reduces the aggregation of neutrophils. The aim of this study was to evaluate the effect of fucoidin on tissue damage in rat electrical burn injury model. Methods: Forty-two male Wistar albino rats (250-300 g) were divided into 3 groups (Group A (n = 6), control group without electrical burn injury; Groups B (n = 18) and C (n = 18), electrical burn injury groups without and with fucoidin therapy, respectively). Three separate analyses were performed at different time points on 6 out of 18 mice from Group B and C at each time point. Biochemistry (myeloperoxidase and malondialdehyde levels) and histopathology (number of neutrophils) of the skin and muscle biopsies at 1st hour; tissue edema (ratio of wet weight/dry weight of extremities) at 24th hour; and necrotic areas at 7th day after electrical injury were evaluated. The electrical burn was induced by exposing rats to 220 V AC between their left upper extremity and right lower extremity for 10 s. Fucoidin was administered as 25 mg/kg intravenous bolus injection at 15 mm after electrical burn injury. Results: Myeloperoxidase and malondialdehyde levels, number of neutrophils, tissue edema, and necrotic area were significantly less in fucoidin-applied rats than the group without fucoidin therapy. Conclusions: Fucoidin inhibits tissue damage induced by electrical burn injury in rats by reducing necrotic area, edema and number of neutrophils. (C) 2011 Elsevier Ltd and ISBI. All rights reserved.
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    Retro-Orbital Intraconal Fat Injection: An Experimental Study in Rabbits
    (W B Saunders Co-Elsevier Inc, 2012) Cakir, Beyhan; Aygit, Ahmet Cemal; Omur-Okten, Ozerk; Yalcin, Omer
    Purpose: Despite adequate treatment, enophthalmos due to intraconjunctival corticosteroid injection and enlargement of the bony orbit after trauma remains a frequent complication. The use of alloplastic material in addressing this problem is restricted because it may result in allergic reactions and is not cost-effective. The use of retro-orbital intraconal injection is the most effective method for maximum augmentation. An inexpensive and minimally invasive alternative that also allows for reoperation when needed would be a preferred intervention. Materials and Methods: We used 24 white rabbits (New Zealand) in our study. The animals were divided into 2 groups: a fat group and a saline solution group. The first group was subjected to retrobulbar fat injection, and the second group underwent physiologic saline solution injection. The volume of the retrobulbar area was measured and statistically evaluated both before and after the injections. Sonographically measured retrobulbar volumes were then statistically analyzed. Results: When the saline solution and fat groups were compared, no significant difference was observed between the preinjection volumes of the orbits. However, after injection, there was a significant difference between volumes. A statistically significant difference was shown between retroorbital volumes calculated before the injection in the fat group and volumes calculated immediately after injection and in the following 4 months (right retro-orbital volume of 1.291 cm(3) +/- 0.031 cm(3) before injection and 2.656 cm(3) +/- 0.040 cm(3) in the fourth month, P < .05). Conclusions: Volume augmentation by fat injection is superior to complicated surgical methods because of the advantages of decreased morbidity, rapid rehabilitation, and ease of reinjection. Using fat tissue as a filling material is more reliable, easier, and cheaper in comparison to other implantable materials. (C) 2012 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 70:242-250,2012