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Öğe Acute Effects of Intermittent Exercise Performed at Anaerobic Threshold Level on Vascular Function in Healthy Young Men(Wiley, 2019) Sen, Burcu; Solak, Serdar; Tayfur, Pinar; Aydogdu, Nurettin; Sut, Necdet; Vardar, Selma Arzu[Abstract Not Available]Öğe The alteration of asymmetric dimetilarginine (ADMA) levels in cardiac and gastrocnemius muscles following radioactive iodine application in guinea pigs and the effect of L-carnitine on this alteration(Taylor & Francis Ltd, 2011) Vardar, Selma Arzu; Gunduz, Ozgur; Altun, Gulay Durmus; Aydogdu, Nurettin; Karadag, Hakan; Torun, Nese; Kaya, OktayPurpose: Tissue levels of asymmetric dimetilarginine (ADMA) and symmetric dimetilarginine (SDMA) were investigated in cardiac ventricle and gastrocnemius muscles of guinea pigs treated with radioactive iodine (RAI) alone or in combination with L-carnitine (LC). Material and methods: Group 1 received no treatment (control group). Group 2 received a total dose of 30 mCi(-1)kg(-1) body weight iodine-131 alone. Group 3 received 200 mg(-1)kg(-1) of LC for 10 days alone. Group 4 received 200 mg(-1)kg(-1) of LC plus RAI therapy. Free thyroid hormones, ADMA and SDMA concentrations were measured. Results: Serum free thyroid hormone concentrations were found decreased in the RAI and LC-RAI groups after RAI application. A significant decrease in ADMA and SDMA concentration was observed in ventricle muscle following RAI application. The LC-RAI group had significantly decreased ADMA levels in ventricle muscle compared with those of the control group. Similarly, SDMA concentrations in ventricle and gastrocnemius muscles of the LC-RAI groups were significantly lower than those of the control groups. Conclusions: Our results indicated that RAI appears to exert an inhibitory effect on ADMA and SDMA levels of ventricular muscle. LC administration when given adjuvant to RAI therapy may cause a marked decrease in ADMA concentrations of both ventricular and gastrocnemius muscles.Öğe The antioxidant effects of taurine, melatonin and N-acetylcysteine in cadmium-induced lung injury(Ekin Tibbi Yayincilik Ltd Sti-Ekin Medical Publ, 2007) Aydogdu, Nurettin; Erbas, Hakan; Kaymak, KadirObjectives: The potential protective and therapeutic effects of taurine, melatonin and N-acetylcysteine (NAC), which are recognized as antioxidant agents, in cadmium chloride (CdCl2)-induced lung injury were compared. Study Design: Ninety male Sprague-Dawley rats were divided into 9 groups. During the 3 months treatment period, group 1 received drinking water, group 2 200 ppm CdCl2, group 3 200 ppm CdCl2 and 1 % taurine, to, group 4, 200 ppm CdC12 and 0.02% melatonin, and group 5 received 200 ppm CdCl2 and 0.5% NAC all added into drinking water in each group. After, groups 6, 7, 8 and 9 received 200 ppm CdC12 in their drinking water for 3 months, group 6 was given drinking water, group 7, 4% taurine, group 8, 0.08% melatonin and group 9, 2% NAC, each for 7 days. Results: Melatonin and NAC which were given for protective purposes, increased the decreased glutathione levels. The 3 substances that were administered for both protective and therapeutic purposes, decreased the increased malondialclehyde levels, one of the end products of lipid peroxiclation. Conclusion: Taurine, melatonin and NAC play protective and therapeutic roles in CdC12 induced lung injury.Öğe Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats(W J G Press, 2006) Soylu, Ali Riza; Aydogdu, Nurettin; Basaran, Umit Nusret; Altaner, Semsi; Tarcin, Orhan; Gedik, Nursal; Umit, HasanAIM: To investigate whether antioxidants vitamin E and C can retard development of hepatic fibrosis in the biliary-obstructed rats. METHODS: Fifty Wistar albino rats were randomly assigned to 5 groups (10 rats in each). Bile duct was ligated in 40 rats and they were treated as follows: group vitC, vitamin C 10 mg/kg sc daily; group vitE, vitamin E 15 mg/kg sc daily; group vitEC, both of the vitamins; bile duct-ligated (BDL, control) group, physiological saline sc. The fifth group was assigned to sham operation. At the end of fourth week, the rats were decapitated, and hepatic tissue biochemical collagen content and collagen surface area were measured. Hepatic tissue specimens were histopathologically evaluated according to Scheuer system. Serum hyaluronate levels were measured by ELISA method. RESULTS: Despite being higher than sham group, hepatic collagen level was significantly decreased in each of the vitC, vitE and vitEC groups (32.7 +/- 1.2, 33.8 +/- 2.9, 36.7 +/- 0.5 mu g collagen/mg protein, respectively) compared to BDL (48.3 +/- 0.6 mg collagen/g protein) (P < 0.001 for each vitamin group). Each isolated vitamin C, isolated vitamin E and combined vitamin E/C supplementation prevented the increase in hepatic collagen surface density (7.0% +/- 1.1%, 6.2% +/- 1.7%, 12.3% 2.0%, respectively) compared to BDL (17.4% +/- 5.6%) (P < 0.05 for each). The same beneficial effect of vitamin C, vitamin E and combined vitamin E/C treatment was also observed on the decrease of serum hyaluronate levels compared to BDL group (P < 0.001). The relative liver and spleen weights, serum transaminases, cholestatic enzymes, bilirubins and histopathological inflammation scores were not different between the antioxidant treatment groups and the control. However, fibrosis staging scores were obviously reduced only in the vitamin E/C combination group (vit EC: 2.4 +/- 0.8 vs BDL: 3.1 +/- 0.7; P < 0.05). CONCLUSION: Each antioxidant vitamin E, vitamin C and their combination retard hepatic fibrosis in biliary-obstructed rats. Oxidative stress may play a role in the pathogenesis of hepatic fibrosis in secondary biliary cirrhosis. (C) 2006 The WJG Press. All rights reserved.Öğe Asymmetric dimethylarginine in experimental breast cancer; action of Vitamin C and E(Pakistan Medical Assoc, 2015) Erbas, Hakan; Turksever, Aylin; Aydogdu, Nurettin; Cakir, ErolObjective: To investigate the arginase-nitric oxide synthase paradox through asymmetric dimethylarginine, symmetric dimethylarginine and nitric oxide levels, and to see the effect of antioxidant vitamins on this mechanism of cancer action. Methods: The animal-based study was conducted at Trakya University, Turkey, in 2008, and comprised mice that were divided into five equal groups. Group 1 had healthy controls, while in the other four groups breast cancer was induced. Group 2 received saline solution, group 3 received 200 mg/kg/day vitamin C (tumour +vit C), group 4 received 300 mg/kg/day vitamin E (tumour +vitE) and group 5 received both 200 mg/kg/day vitamin C and 300 mg/kg/day vitamin E (tumour +vit C+vit E) for 15 days intra-peritoneally. Arginine, asymmetric dimethylarginine, symmetric dimethylarginine and nitric oxide levels were determined in each group. Results: The 50 mice in the study were divided into five groups of 10(20%) each. Plasma arginine levels were significantly decreased, asymmetric dimethylarginine and symmetric dimethylarginine levels were increased, while plasma nitric oxide level was significantly decreased in group 2. There was no statistically significant difference in treatment groups for all parameters (p>0.05 each). Conclusion: Understanding of the mechanism may help to develop new anti-cancer agents.Öğe Capecitabine-related intracranial hypotension syndrome mimicking dural metastasis in a breast cancer patient: Case report and review of the literature(Medknow Publications, 2010) Cosar-Alas, Rusen; Alas, Aykan; Ozen, Alaattin; Denizli, Bengu; Saynak, Mert; Uzunoglu, Sernaz; Aydogdu, NurettinSpontaneous intracranial hypotension (SICH) is an entity, which is secondary to iatrogenic manipulation and breaching of dura. Postural headache in patients should be suspected, cranial magnetic resonance imaging (MRI) is essential for precise diagnosis. Hallmark of MRI is regular shape of pachymeningeal gadolinium enhancement and subdural effusion. It may mimic central nervous system (CNS) metastasis. Prevention of such cases from receiving cranial radiotherapy by misinterpretation of the gadolinium enhancement as CNS metastasis is an important issue. Capecitabine is an antineoplastic agent, of which metabolites can cross blood-brain barrier in CNS via epithelial tissue. It may cause decrease in CSF production. SICH might be the clinical reflection of this decrease in CSF production. Review of the English literature revealed limited data because of the very little experience with oncologic patients suffering from intracranial hypotension. We report a case of spontaneous intracranial hypotension during capecitabine treatment. Patient was completely well following drug discontinuation and supportive treatment.Öğe The comparison of endothelial function of moderate intensity interval exercise with continuous exercise in healthy men(Elsevier, 2022) Meric, Burcu; Solak, Serdar; Aydogdu, Nurettin; Sut, Necdet; Vardar, Selma ArzuBackground/aim: Exercise enhances endothelium-dependent vasodilation; however, it is unclear whether intermittent exercise has a different effect on vascular endothelial function compared to continuous exercise. This study aimed to compare vascular endothelial function following intermittent exercise including short rest intervals with continuous exercise, both at the anaerobic threshold level. Materials and methods: Peak oxygen consumption (VO2 peak) and anaerobic threshold were measured in physically active healthy young men (n = 12) by breath-by-breath analysis. After completion of intermittent exercise consisting of eight 1-min long intervals at the anaerobic threshold intensity with 75-s rest periods, total work was calculated. Equivalent work was done during continuous exercise. Immediately after the two exercise periods, venous blood lactate, endothelial nitric oxide synthase (eNOS), endothelin-1, N-terminal proANP (NTproANP), N-terminal proBNP (NTproBNP), and N-terminal proCNP (NTproCNP) levels were measured. Brachial artery flow-mediated dilatation (FMD) was measured before exercise and 30 min after exercise. Results: Mean VO2 peak level was 33.42 +/- 5.9 ml/min/kg and anaerobic threshold level was 47.33 +/- 5.85%. Lactate levels following continuous exercise were higher than levels following intermittent exercise (27.76 +/- 7.43 mg/dl, 18.54 +/- 4.87 mg/dl respectively; p.0.05). Endothelin-1, eNOS, NTproANP, NTproBNP, and NTproCNP levels were similar after both modalities of exercise (p > 0.05). No significant difference was found in FMD response when comparing intermittent and continuous exercise (7.05 +/- 15.11%, 2.49 +/- 16.24% respectively; p > 0.05). Conclusion: Since blood lactate levels are higher following continuous exercise, individuals who find difficulty exercising may prefer an intermittent form of exercise. However, both intermittent and continuous exercise at the anaerobic threshold level seem to not produce a significant acute change in endothelial function in healthy men.Öğe Effect of curcumin on ipsilateral and contralateral testes after unilateral testicular torsion in a rat model(Karger, 2008) Basaran, Umit Nusret; Dokmeci, Dikmen; Yalcin, Omer; Inan, Mustafa; Kanter, Mehmet; Aydogdu, Nurettin; Turan, NesrinObjective: The aim of the study was to determine the protective effect of curcumin on testicular ischemia- reperfusion ( I/ R) injury. Materials and Methods: 32 male rats were divided into four groups ( n = 8): group 1: control; group 2: ischemia; group 3: I/ R, and group 4: I/ R+CUR. Curcumin ( 150 mg/ kg, p. o.) was administered before 30 min of reperfusion in group 4. Malondialdehyde ( MDA) levels, Johnsen's testicular biopsy scores, and mean seminiferous tubule diameter measurements were evaluated in testes. In addition, endothelial nitric oxide synthase ( eNOS) and inducible nitric oxide synthase ( iNOS) expressions were evaluated immunohistochemically. Results: MDA levels in control groups were significantly lower than other groups in ipsilateral and contralateral testes. Johnsen's scores in the control group were significantly higher than in other groups. MDA levels and Johnsen's scores in the I/ R+ CUR group were similar to the ischemia and I/ R groups in ipsilateral and contralateral testes. The immunoreactivity of iNOS and eNOS were increased in I/ R ipsilateral testicular groups. After I/ R, iNOS and eNOS expression increased slightly in contralateral groups. Additionally, the curcumin treatment decreased iNOS and eNOS immunoreactivity in ipsilateral and contralateral testes. Conclusion: The results suggest that curcumin did not protect the unilateral nor contralateral testes. This observation may depend on inhibition of iNOS and eNOS due to inhibition of the antioxidant, anti- inflammatory effects of nitric oxide. Copyright (C) 2008 S. Karger AG, Basel.Öğe The effect of melatonin on cadmium-induced renal injury in chronically exposed rats(Aves, 2009) Kaplan, Mustafa; Atakan, Irfan Huseyin; Aydogdu, Nurettin; Aktoz, Tevfik; Puyan, Fulya Oz; Seren, Gulay; Tokuc, BurcuObjective: This study was designed to investigate the effects of melatonin as an antioxidant, in prevention and treatment of cadmium (Cd)-induced renal toxicity in rats. Materials and methods: Fifty adult male Sprague-Dawley rats weighing 340 to 370 g were used. Renal toxicity was induced with the use of 200 mu g/ml of cadmium chloride in tap water. Ten rats were assigned to receive only tap water as the control group for three months and seven days. Two study groups were designed. To investigate the ability of melatonin to prevent Cd damage (Study 1), 10 rats received Cd and 10 rats received Cd plus 0.02% co-treatment melatonin in tap water for three months. To test whether melatonin would reverse CD-induced damage to the kidney (Study 2), 10 rats received Cd in tap water for three months+7 days, and 10 rats received Cd for three months followed by administration of high-dose (0.08%) melatonin in tap water for seven days. Results: Cadmium exposure significantly increased the kidney malondialdehyde (MDA) levels, as a marker of lipid peroxidation, decreased the kidney superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities, increased Cd concentrations in the renal cortex, but did not change glomerular filtration rate (GFR) and fractional excretion of sodium (FE-Na). In Study 1, melatonin decreased MDA levels, increased SOD, CAT and GSH-Px activities. In Study 2, melatonin decreased the kidney MDA levels, increased the SOD activity, but did not change the CAT and GSH-Px activities. Kidney accumulation of Cd did not change in both melatonin-treated groups. Histopathologically, Cd intake affected proximal tubules of the nephron more than the glomerular parts. Melatonin did not change these alterations. Conclusion: Our findings suggest that Cd-induced renal toxicity is related with oxidative stress and exogenously administrated melatonin might reduce the toxic effects of Cd on kidney without any reduction in tissue Cd burden.Öğe The effects of erdosteine on experimental myoglobinuric acute kidney injury in rats(Wiley-Blackwell, 2015) Bana, Cigdem Atagun; Aydogdu, Nurettin; Tastekin, Ebru; Poyraz, Meryem Demircan; Yavuz, Ozlem Yalcinkaya[Abstract Not Available]Öğe The Effects of Irisin on Experimental Hypertension in Rats(Wiley, 2017) Aydogdu, Nurettin; Tastekin, Ebru; Tayfur, Pinar; Yavuz, Ozlem Yalcinkaya; Kaya, Oktay; Kandemir, Nihayet[Abstract Not Available]Öğe Effects of Losartan on Glycerol-induced Myoglobinuric Acute Renal Failure in Rats(Kafkas Univ, Veteriner Fakultesi Dergisi, 2013) Kaya, Oktay; Aydogdu, Nurettin; Tastekin, Ebru; Karadag, Cetin Hakan; Gunduz, Ozgur; Sut, NecdetMyoglobinuric acute renal failure (mARF) is an uremic syndrome which develops due to damage of skeletal muscle. It was demonstrated that free radicals and nitric oxide (NO) play an important role in pathogenesis of mARF. Our aim was to investigate the effect of losartan, a drug known for its antioxidant effect, on mARF. In our study, a total of 34 male Spraque Dawley rats were divided into four groups. 1st and 2nd groups were injected with saline, 3rd and 4th groups were injected with intramuscular glycerol. One and 24 hours later, 1st and 3rd groups received saline orally and 2nd and 4th groups have taken 10 mg/kg losartan. Urine was collected; the blood samples and kidneys of the rats were taken under the anesthesia. The levels of NO, arginine, asymmetric dimethylarginine (ADMA), glutathione (GSH) and malondialdehyde (MDA) were determined, renal functions and histopathological changes examined. In our study, we found that levels of urea, creatinine, and potassium, in serum samples and MDA and ADMA in renal tissue were increased in 3rd group when it's compared with the 1st group. Levels of sodium, arginine in serum samples and arginine in renal tissue were reduced 3rd group when compared with the 1st group. When 3rd and 4th groups were compared, serum creatinine was higher in the latter group whereas ADMA level in renal tissue was lower in the same group. We think that there is no positive effect of losartan on the pathogenesis of mARF.Öğe The Effects of Lycopene on Experimental Renal Ischemia/Reperfusion Injury(Wiley-Blackwell, 2015) Poyraz, Meryem Demircan; Aydogdu, Nurettin; Tastekin, Ebru; Sut, Necdet[Abstract Not Available]Öğe The Effects of Lycopene on Myoglobinuric Acute Kidney Injury(Wiley-Blackwell, 2015) Uzun, Semiha; Aydogdu, Nurettin; Tastekin, Ebru[Abstract Not Available]Öğe The effects of taurine, melatonin and acetylcysteine on nitric oxide, lipid peroxidation and some antioxidants in cadmium induced liver injury(Erciyes Univ Sch Medicine, 2007) Aydogdu, Nurettin; Kanter, Mehmet; Erbas, Hakan; Kaymak, KadirPurpose: Our aim was to investigate both the potential protective and therapeutic effects of taurine, melatonin and acetylcysteine in cadmium induced liver injury. Material and Methods: Ninety male Spraque Dawley rats were divided into nine groups. For the three months treatment period, drinking water was administered to Group 1 whereas 200 ppm CdCl2 to Group 2, 200 ppm CdCl2 and 1% taurine to Group 3, 200 ppm CdCl2 and 0.02% melatonin to Group 4 and 200 ppm CdCl2 and 0.5%acetylcysteine to Group 5. Groups 6, 7, 8 and 9 received 200 ppm CdCl2 in their drinking water for 3 months. After this period, for 7 days, 4% taurine to group 7, 0.08% melatonin to Group 8 and 2% acetylcysteine to group 9 were applied. Results: In liver tissues of cadmium received rats, the levels of glutathione (GSH) and the enzyme activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) were decreased. Thiobarbituric acid reactive substances (TBARS), nitric oxide (NO) and inducible nitric oxide synthase (iNOS) activities were increased. While, taurine, melatonin and acetylcysteine increased GSH levels, SOD and GPx activities, it decreased TBARS, NO and iNOS activities. Conclusion: Taurine, melatonin and acetylcysteine may have both protective and therapeutic effects in cadmium induced liver injuries.Öğe The Effects of Taurine, Melatonin and N-Acetylcystein on Cadmium Exposure Bone Changes The Surprising Effect of Taurine(Gazi Univ, Fac Med, 2020) Tastekin, Nurettin; Aydogdu, Nurettin; Altun, Gulay Durmus; Erbas, Hakan; Uzunca, Kaan; Birtane, Murat; Kaplan, MustafaBackground: Chronic environmental and occupational exposure to cadmium can result in skeletal system changes. The main objective of the present study was to investigate and compare the effects of taurine, melatonin and N-acetyl cysteine on cadmium exposure induced bone density loss. Methods: 90 adult male Sprague-Dawley rats were allocated into four main groups: Group I was the control group; Group II was the cadmium exposure group; Group 3 was cadmium exposure for 3 months + concurrent antioxidant administration group. The concept of Group 4 was cadmium exposure for 3 months + subsequent antioxidant administration. Bone mineral density values were evaluated in all the groups. Serum calcium, phosphorus, alkaline phosphatase (ALP) enzyme activities and 24 hours urine calcium excretion levels were measured. Kruskal-Wallis test was used to compare the all groups. Between two group comparisons, the Mann-Whitney U test was used. Results: There was no significant difference in terms of bone mineral density values only between control group and cadmium exposure group (p 0.05). Mean bone mineral density values obtained in cadmium + concurrent taurine and cadmium + subsequent taurine groups were significantly lower than all the other groups (p<0.05). 24 hours urine calcium excretion levels were significantly higher in groups which taurine and n-asetylcystein were administered after cadmium exposure. Conclusion: Taurine, which is thought to have protective effects as an antioxidant caused a marked bone damage after exposure to cadmium. Further studies are needed to clarify this effect of taurine.Öğe Effects of vitamins E and C supplementation on hepatic glutathione peroxidase activity and tissue injury associated with ethanol ingestion in malnourished rats(Elsevier Science Inc, 2006) Soylu, Ali Riza; Altaner, Semsi; Aydogdu, Nurettin; Basaran, Umit Nusret; Tarcin, Orhan; Gedik, Nursal; Umit, HasanBackground: Oxidative stress has been associated with tissue injury in alcoholic liver disease. Although this close association is well known, whether prevention of oxidative stress retards tissue injury has not been thoroughly investigated. Objective: The aim of this study was to determine the effects of supplementation with vitamins E and C on antioxidant enzyme status and histologic changes in hepatic tissue in a rat model of alcoholic liver disease. Methods: This 8-week, blinded, controlled study was conducted at the Department of Internal Medicine, Trakya University, Edirne, Turkey. Weanling albino female protein-deficient Wistar rats weighing similar to 200 g were randomly assigned to I of 6 groups: (1) liquid diet + ethanol + vitamin E 15 mg/kg PO (LDetvitE); (2) liquid diet + ethanol + vitamin C 10 mg/kg PO (LDetvitC); (3) liquid diet + ethanol + vitamin E 15 mg/kg + vitamin C 10 mg/kg PO (LDetvitEC); (4) liquid diet + ethanol (LDet); (5) liquid diet + isocaloric sucrose (LDS); and (6) normal diet (control). The primary end point of the study was to determine whether antioxidant vitamin E/C combination therapy prevents development of hepatic fibrosis (ie, cirrhosis in a period of 1 year). After being euthanized at week 8, the rats were weighed, and their livers and spleens were weighed. Hepatic tissue specimens were histopathologically assessed according to the Brunt system. Hepatic tissue glutathione peroxidase, superoxide dismutase, and catalase activities were determined. Biochemical tissue collagen concentrations were measured to determine the presence of hepatic fibrosis. Results: Seventy-two rats were included in the study (mean [SE] weight, 205 [21] g) (12 rats per group). Initially planned to last 48 weeks, the study was terminated at 8 weeks due to the death of 3 rats in each group (except the LDS group and control group). The relative liver weight was significantly lower in the LDetvitEC group compared with that in the LDet group (mean [SE], 3.7% [0.5%] vs 4.8% [0.9%]; P < 0.01). Mean (SE) hepatic tissue glutathione peroxidase activity was significantly reduced in the LDet-treated rats compared with controls (1.2 [0.2] vs 2.6 [0.3] U/mg protein; P < 0.001). The groups that received supplementation with vitamin E, vitamin C, and vitamins E and C combined had significantly more hepatic glutathione peroxidase activity (mean [SE], 2.1 [0.5], 2.5 [0.2], and 2.6 [0.7] U/mg protein, respectively) compared with the LDet group (1.2 [0.2] U/mg protein) (all, P < 0.001). No significant between-group differences in hepatic superoxide dismutase or catalase activities were found. Compared with controls (14.5 [1.9] mu g collagen/mg protein), the mean (SE) histologic hepatic collagen concentration was significantly higher in all groups (19.2 [1.2], 19.5 [3.3], 18.5 [3.0], 25.9 [3.3], and 21.6 [1.5] mu g collagen/mg protein in the LDetvitE, LDetvitC, LDetvitEC, LDet, and LDS groups, respectively; P < 0.01, P < 0.01, P < 0.05, P < 0.001, and P < 0.001, respectively). Compared with the LDet group, the mean hepatic collagen concentration was significantly lower in the LDetvitE, LDetvitC, and LDetvitEC groups (P < 0.01, P < 0.05, and P < 0.01, respectively). The LDetvitEC group had a significantly lower mean (SE) hepatic inflammatory score compared with the LDet group (0.8 [0.1] vs 1.3 [0.2]; P < 0.05). The LDetvitEC group had a significantly lower mean (SE) hepatic necrosis score compared with that in the LDet group (1.5 [0.2] vs 2.4 [0.3]; P < 0.05). Conclusions: The results of this study in protein-deficient rats fed with a high-fat liquid diet suggest that supplementation with vitamin E, vitamin C, and a combination of vitamins E and C was associated with decreased ethanol-induced hepatic glutathione peroxidase activity and hepatic fibrosis, and that supplementation with vitamins E and C might have attenuated the development of hepatomegaly and hepatic necroinflammation, whereas this result was not found in the group given a liquid diet and ethanol in this 8-week study.Öğe Indomethacin-induced gastric damage in rats and the protective effect of donkey milk(Termedia Publishing House Ltd, 2018) Tastekin, Ebru; Ayvaz, Suleyman; Usta, Ufuk; Aydogdu, Nurettin; Cancilar, Ekrem; Puyan, Fulya OzIntroduction: Indomethacin is an anti-inflammatory drug with clearly known side effects on gastric mucosa. New treatment and side effect prevention methods are being studied. Donkey milk, as a nutritional support, has recently come into the spotlight with its anti-oxidant features, high antibody content and low allergenic properties. In this study, we investigated donkey milk's possible protective effect against acute gastric mucosal damage by indomethacin. Material and methods: Four groups, each composed of 8 rats, were created. Rats in the first and third groups were fed with standard rat chow, while those in the second and fourth groups were additionally fed with 25 mg/kg of donkey milk per day via nasogastric gavage. On the 11th day gastric mucosal damage was induced by oral administration of 30 mg/kg of indomethacin to the rats in groups 3 and 4. Six h later all rats were sacrificed and their stomachs were removed for macroscopic and microscopic evaluation as well as biochemical examination of glutathione (GSH) and malondialdehyde (MDA) levels. Tumor necrosis factor-alpha (TNF-alpha) expression in the gastric mucosa was evaluated immunohistochemically. Results: In the donkey milk-indomethacin group, total area of erosion and degree of linear ulceration were significantly lower than in the standard food-indomethacin group (p < 0.05). Also, GSH levels were increased and MDA levels were decreased significantly in this group. Tumor necrosis factor-alpha expression was more prevalent and stronger in the gastritis group, while lower expression was observed in the donkey milk group. Conclusions: Donkey milk was observed to have significant protective effects against gastric damage induced by indomethacin.Öğe Influence of N-acetylcysteine on renal toxicity of cadmium in rats(Springer, 2008) Kaplan, Mustafa; Atakan, Irfan H.; Aydogdu, Nurettin; Aktoz, Tevfik; Ozpuyan, Fulya; Seren, Guelay; Tokuc, BurcuThe aim of this study was to investigate the ability of N-acetylcysteine (NAC) to prevent cadmium (Cd)-induced renal damage and whether NAC would reverse cadmium damage to the kidney. Fifty adult male rats were divided into five experimental groups: group 1 received tap water for 3 months and 7 days, group 2 received cadmium chloride (CdCl2) for 3 months, group 3 (NAC cotreatment group) received CdCl2 and 0.5% NAC in tap water for 3 months, group 4 received CdCl2 in tap water for 3 months and 3 months later received only tap water for 7 days, and group 5 (NAC posttreatment group) received CdCl2 in tap water for 3 months and 3 months later received 2% NAC in tap water for 7 days. NAC significantly decreased the elevated kidney malondialdehyde levels, as a marker of lipid peroxidation, in both cotreatment and posttreatment modalities. Cotreatment and posttreatment with NAC significantly increased kidney superoxide dismutase enzyme activity and glutathione level but did not change kidney catalase enzyme activity. NAC decreased fractional excretion of sodium in posttreatment group. Neither Cd nor NAC affected the glomerular filtration rate (GFR). Cotreatment and posttreatment with NAC reduced the effects of Cd on proximal tubules. It was found that NAC showed these effects without changing kidney accumulation of cadmium. Exogenously administrated NAC might reduce toxic effects of Cd on the kidney without any reduction in tissue Cd level.Öğe Investigation of Adropin Levels in Experimental Myoglobinuric Acute Kidney Injury(Karger, 2018) Iskan, Nur Gulce; Soyleyici, Begum; Kandemir, Nihayet; Aydin, Muhammed Ali; Kudaibergenova, Assel; Aydogdu, Nurettin[Abstract Not Available]
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