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    Changes in expression of miRNAs associated with nuclear factor kappa B in experimental acute respiratory distress syndrome
    (Wiley, 2018) Azizoglu, M.; Ayaz, L.; Bayrak, G.; Yilmaz, B. Coskun; Birbicer, H.; Doruk, N.
    [Abstract Not Available]
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    Circulating microRNA expression profiles in ovarian cancer
    (Taylor & Francis Inc, 2014) Ayaz, L.; Cayan, F.; Balci, S.; Gorur, A.; Akbayir, S.; Yaroglu, H. Yildirim; Unal, N. Dogruer
    MicroRNA (miRNA) is an abundant class of small non-coding RNAs that act as gene regulators. Recent studies have suggested that miRNA deregulation is associated with the initiation and progression of human cancer. However, information about ovarian cancer-related miRNA is mostly limited to tissue miRNA. The aim of this study was to find specific profiles of plasma-derived miRNAs of ovarian cancer. In this present study, the expression profiles of 740 miRNAs in plasma from 18 patients and 24 healthy women subjects were evaluated using microfluidic based multiplex qRT-PCR. Our results demonstrated that expression levels of eight miRNAs were significantly upregulated in patients with ovarian cancer when compared with a control group (p < 0.05). Expression levels of four miRNAs were found significantly downregulated in patients with ovarian cancer (p < 0.05). In addition, 10 miRNAs were expressed only in the ovarian cancer group and miR-138-5p of these miRNAs is ovarian specific. In conclusion, our study suggests that detecting these ovarian cancer specific miRNAs in plasma might serve as novel non-invasive biomarkers for ovarian cancer.
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    Differential expression of microRNAs in plasma of patients with larygeal squamous cell carcinoma: potential early detection markers for larygeal squamous cell carcinoma
    (Wiley-Blackwell, 2013) Ayaz, L.; Gorur, A.; Yaroglu, H. Y.; Dogruer, N. U.; Fidanci, S. B.; Ozcan, C.; Tamer, L.
    [Abstract Not Available]
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    Effects of intravitreal injection of bevacizumab on nitric oxide levels
    (Nature Publishing Group, 2015) Dinc, E.; Yildirim, O.; Ayaz, L.; Ozcan, T.; Yilmaz, S. N.
    Purpose This study aimed to determine the possible effects of single-dose intravitreal bevacizumab on nitric oxide (NO) levels in serum and remote organs and to reveal one of the possible mechanisms in the pathophysiology of hypertension. Methods Thirty-eight adult New Zealand albino rabbits were divided into a control group (no injection was performed, killed on day 28 of the study), group 1 (killed on day 1 of the study), group 2 (killed on day 7 of the study), group 3 (killed on day 14 of the study), and group 4 (killed on day 28 of the study). The right eyes of the animals in groups 1-4 received an intravitreal single injection of 1.25mg (0.05ml) bevacizumab (Avastin), and their brain, heart, liver, kidney, and blood samples were collected. NO levels were evaluated in the serum and organ homogenates. Kidney tissues were assessed by electron microscopy. Results Serum, brain, kidney, and liver NO levels significantly decreased in groups 2, 3, and 4 as compared with the control group (P<0.05). In addition, heart NO levels significantly decreased in groups 3 and 4 compared with the control group (P<0.05). There were no electron microscopic changes in the kidneys of either group. Conclusions This study demonstrated that single intravitreal injection of bevacizumab decreased NO levels in serum, brain, heart, liver, and kidneys. In addition, there were no electron microscopic changes in the kidneys.
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    microRNA expression signatures between non-atherosclerotic plaque and atherosclerotic plaque in CAD with humans, and parallels whole blood
    (Wiley-Blackwell, 2016) Ayaz, L.; Ercan, B.; Sucu, N.; Tanriverdi, K.; Tamer, L.
    [Abstract Not Available]
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    microRNA profiling for early detection of nonmelanoma skin cancer
    (Wiley-Blackwell, 2016) Balci, S.; Ayaz, L.; Gorur, A.; Yaroglu, H. Yildirim; Akbayir, S.; Unal, N. Dogruer; Bulut, B.
    Background. microRNAs (miRNAs) are single-stranded, noncoding RNA molecules. Given the vast regulatory potential of miRNAs and their often tissue-specific and disease-specific expression patterns, miRNAs are being assessed as possible biomarkers to aid diagnosis and prediction of different types and stages of cancers, including skin cancer. Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most common forms of nonmelanoma skin cancer (NMSC). BCC originates from the basal layer of the epidermis, while SCC arises from epidermal keratinocytes or from the dermal appendages. Although NMSCs are currently the most common types of malignancies, both BCC and SCC have a better than 95% cure rate if detected early. Aim. To identify plasma miRNAs suitable for early detection of NMSC. Methods. Expression profiles of 741 miRNAs were evaluated using high-throughput real-time quantitative PCR from plasma samples in 42 patients with NMSC and 282 healthy controls (HCs). Results. Our results demonstrated that in patients with NMSC, compared with HCs, expression levels of miR-30e-3p, miR-145-5p, miR-186-5p and miR-875-5p were significantly (P < 0.05) upregulated, while those of miR-19a-3p, miR-25-3p, miR-30a-5p, miR-451 and miR-576-3p were significantly downregulated. Conclusion. Our study suggests that the miRNAs with significant changes in expression (miR-19a-3p, miR-25-3p, miR-30a-5p, miR-145-5p and miR-186-5p) could serve as novel noninvasive biomarkers for detection of NMSC.