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    The antimicrobial effect of various formulations obtained from Fomes fomentarius against hospital isolates
    (2019) Gedık, Gulsah; Dulger, Gorkem; Asan, Hulya; Özyurt, Anıl; Allı, Hakan; Asan, Ahmet
    The purpose of this study was to investigate the antimicrobial activity of formulations of F. fomentarius. The antimicrobial efficacy levels of extracts of F. fomentarius prepared from ethanol, water and of various formulations (emulsion, ointment, paste, cream and gel) were determined. For this purpose, the disk diffusion method was used to test the extracts for antimicrobial activity against hospital isolates including Klebsiella pneumoniae, Acinetobacter baumannii, Staphylococcus aureus, vancomycin-resistant enterococci (VRE+), Escherichia coli, Candida krusei, C. albicans, C. tropicalis, C. guilliermondii and C. glabrata. Some standard antibiotics were used for comparison. The ointment formulation (No. 4) showed a good antimicrobial effect on bacteria compared to the antibiotics (9.6 - 16.1 mm.). The extracts were found to be more effective than the antibiotics against Candida species. Formulation No. 4 was considered to be more effective because of the protective nature of its cetyl alcohol and sodium lauryl sulfate (SLS) content . F. fomentarius ethanol extract, F. fomentarius water extract and gel formulation showed similar activity; however, other formulations (emulsion, paste, cream) were generally more effective due to the stabilizing effects of the polymers, oil and alcohols present in their preparations. The findings of this study establish the possibility of discovering new clinically effective antibiotic drugs and could be useful in understanding the relationship between traditional remedies and modern medicines.
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    Effect of gel formulation obtained from Fomes fomentarius on bleeding and clotting time: A pilot study
    (Istanbul Univ, Fac Pharmacy, 2020) Gedik, Gulsah; Asan, Hulya; Ozyurt, Anil; Alli, Hakan; Asan, Ahmet; Nazli, Hakan; Sarp, Onder
    Background and Aims: Fomes fomentarius (L.) Fr. (jar fungus) has been used extensively in the past by surgeons, barbers, dentists, and is therefore called surgeon's fungus. The hemostatic properties of F. fomentarius extracts are important in medicine. The aim of this study was to investigate the effect of the gel formulation obtained from Fames Famentarius on bleeding and clotting time in rat models. Methods: The gel was made for this purpose and a cross-linked polymer of acrylic acid was used as a gelling agent. Results: The outcomes of the characterization analysis indicate the development of a successful gel formulation with optimum characteristics. Data from the antimicrobial study showed a good inhibition zone, with the strongest values against Klebsietta pneumaniae, Candida krusei, C. tropicalis, C. guitliermondii. The gel administration shortened the hemostasis time after bleeding from skin incisions by 63.9% and tail incisions by 55.63% from the original time. For coagulation time, these results are determined as 71.56% from the original time. The gel administration shortened the coagulation time after bleeding from the tail incisions by 69.9% from the original time. Conclusion: Our preliminary study showed that the gel formulation obtained from F. fomentarius is a potent hemostatic agent in a rat-bleeding model.