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    Can myocardial performance index predict early cardiac risks in erectile dysfunction?
    (Taylor & Francis Ltd, 2020) Ardahanli, Isa; Celik, Mehmet
    Aim: Myocardial performance index (MPI) is an easy-to-apply and non-invasive method that shows both systolic and diastolic functions of the heart. In this study, it was aimed to evaluate the relationship between erectile dysfunction (ED) and MPI. Methods: The study included 45 male patients admitted to the urology outpatient clinic for ED and 48 healthy male volunteers. Echocardiographic evaluation of all participants was performed. Isovolumetric contraction time (IVCT), isovolumetric relaxation time (IVRT) and ejection time (ET) were measured. MPI was calculated using the IVCT + IVRT/ET formula. Results: The average age of the study population was 50 +/- 5.3. Early diastolic mitral inflow (E)/late diastolic mitral inflow (A) ratio was significantly lower in the ED group (p <= 0.05). In the TDI evaluation between the groups, while early diastolic mitral annular velocity (Em) was significantly higher in the ED group, there was no significant difference in late diastolic mitral annular velocity (Am) and systolic peak velocities (Sm) (p < 0.01 and p = 0.417 and p = 0.092, respectively). While IVRT was significantly lower in the ED group (p < 0.05), there was no significant difference in IVCT and ET (p = 311 and p = 0.261, respectively). MPI was statistically significantly higher in the ED group (p < 0.05). Conclusion: ED has been found to affect MPI. This parameter, which is easily and non-invasively measured, can be used to predict the risk of CVDs in ED.
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    The Effect of Serum Magnesium Level on Stable Anticoagulation in Patients Using Warfarin for Various Cardiac Indications
    (Springernature, 2022) Ardahanli, Isa; Akhan, Onur; Celik, Mehmet
    Warfarin is a vitamin K antagonist agent that inhibits clotting factors used for long-term anticoagulation. Time in therapeutic range (TTR) in patients using warfarin is one of the primary treatment effectiveness requirements. We aim to investigate the relationship between serum magnesium levels, the international normalized ratio (INR) values, and TTR values in people using warfarin for various indications. Our study is a single-center, cross-sectional, and retrospective study that included 169 patients between 18 and 70 who used warfarin for various indications. Demographic data, biochemical analysis, and coagulation parameters, including TTR calculation, were evaluated for all patients. Those with a TTR value below 60 were defined as labile INR, and those with 60 and above as stable INR group and compared. The mean INR value was higher in the labile INR group than the stable INR group (3.7 +/- 2.9, 3.2 +/- 0.3, respectively; p = 0.030). The Mg values are significantly lower in the labile INR group than the stable group (1.8 +/- 0.2 mg/dL, 2.0 +/- 0.1 mg/dL, respectively; p < 0.001). In binary multivariate logistic regression analysis, magnesium value was the most influential INR stabilization factor (p < 0.001). As a result of our study, it was concluded that magnesium levels are an influential factor in stabilizing INR. We can state that we have contributed to the literature and can be a reference for future studies.
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    Serum Uric Acid Levels among Patients who Died in Recent Year due to Heart Failure with Reduced Ejection Fraction
    (Coll Physicians & Surgeons Pakistan, 2020) Ardahanli, Isa; Celik, Mehmet
    Objective: To examine the relationship of uric acid levels in the last one year with exitus due to heart failure (HF) with clinical and demographic data of patients. Study Design: Cross-sectional, descriptive study. Place and Duration of Study: Bilecik State Hospital, Bilecik, Turkey, from January 2019 to January 2020. Methodology: The files of 90 people who had exitus due to HF were scanned retrospectively. Demographic data and echocardiography results were recorded. Serum uric acid levels were noted in the 2nd month, 6th month, and 12th month by taking the baseline in the last year before exitus. Mean repeated measurements of uric acid levels that changed over time in patients were compared with ANOVA variance analysis. P <0.05 were accepted as statistically significant. Results: The mean of the left ventricular ejection fraction (LVEF) of the patients was 35.6 +/- 6.6%. Mean serum uric acid levels of the patients for one year before excitus were 5.6 +/- 2.2 mg/dL (baseline), 6.1 +/- 2.3 mg/dL (2th month), 7.1 +/- 2.6 mg/dL (6th month), 8.5 +/- 3.0 mg/dL (12th month) respectively. There was a statistically significant difference between the basal uric acid mean with the 6th and 12th month uric acid levels both p <0.001. Age and LVEF were not significantly associated with the uric acid increase over time (p=0.250 and p=0.327, respectively) but were statistically different according to gender (p=0.036). Conclusion: In heart failure with reduced ejection fraction (HFrEF), the uric acid level increases progressively towards the last periods before exitus. This increase is more pronounced in men.