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Öğe Cut-off level for Tc-99m sestamibi cavity/myocardium count ratio in patients with left ventricular hypertrophy(Oxford Univ Press, 2011) Torun, N.; Altun, G. Durmus; Altun, A.[Abstract Not Available]Öğe Does Ramadan modify the circadian patterns?(Medknow Publications, 2006) Altun, A.; Ugur-Altun, B.[Abstract Not Available]Öğe Early and intermediate-term outcomes in patients with reversible myocardial perfusion defects on 99mTc MIBI SPECT, and normal coronary angiograms(Springer, 2008) Alpay, M.; Durmus-Altun, G.; Altun, A.; Aktoz, M.; Berkarda, S.[Abstract Not Available]Öğe Evaluation of early cardiac dysfunction in patients with systemic lupus erythematosus with or without anticardiolipin antibodies(Sage Publications Ltd, 2015) Barutcu, A.; Aksu, F.; Ozcelik, F.; Barutcu, C. A. E.; Umit, G. E.; Pamuk, O. N.; Altun, A.The aim of this study was to use transthoracic Doppler echocardiographic (TTE) imaging methods to identify cardiac dysfunction, an indicator of subclinical atherosclerosis in asymptomatic systemic lupus erythematosus (SLE) patients in terms of cardiac effects. This study involved 80 patients: a study group (n=50) and control group (n = 30). They were categorized into four subgroups: anticardiolipin antibodies (aCL) (+) (n = 14) and aCL (-) (n = 36); systemic lupus erythematosus disease activity index (SLEDAI) >= 6 (n = 15) and SLEDAI < 6 (n = 35); disease period >= 5 years (n = 21) and disease period < 5 years (n = 29); major organ involvement (+) (n = 19), major organ involvement (-) (n = 31). The ratio of mitral peak velocity of early filling to early diastolic mitral annular velocity (E/E') for the study group was found to be higher than the control (p < 0.01). Systolic septal motion velocity (Ssm) was lower in the study group compared with the control (p < 0.01). Left atrium (LA) dimension was greater in the study group than the control (p < 0.01). Ssm was found to be lower in the aCL (+) patients compared with the control and aCL (-) groups (p < 0.01, p < 0.05, respectively). LA dimension was greater in the aCL (+) and (-) groups compared with the control, (p < 0.01, p < 0.05, respectively) and aCL groups compared with each other (p < 0.05). The E/E' ratio for the aCL (+) and (-) groups was found to be greater than the control (p < 0.05). In the study, both the Ssm and the late diastolic septal velocity (sA') was found to be lower in the SLEDAI >= 6 group compared with SLEDAI < 6 group, (p < 0.001, p < 0.05, respectively). LA dimension was statistically greater in the SLEDAI >= 6 group compared with the SLEDAI < 6 group (p < 0.001). E' and early diastolic septal velocity (sE') were statistically lower in the disease period > 5 years group compared with the disease period < 5 years group (p < 0.01, p < 0.05, respectively). Carrying out regular scans with TTE image of SLE patients is important in order to identify early cardiac involvement during monitoring and treatment. Identifying early cardiac involvement in SLE may lead to a reduction in mortality and morbidity rates.Öğe The impact of everolimus on pulmonary damage with radiotherapy: Results of an experimental study(Elsevier Sci Ltd, 2015) Eren, M.; Eren, A. Ay; Yucel, B.; Ozguven, Y.; Matsuno, R. K.; Altun, A.; Kilickap, S.[Abstract Not Available]Öğe The impact of everolimus on radiation-induced pulmonary fibrosis in wistar albino rats: Results of an experimental study(Amer Assoc Cancer Research, 2016) Eren, M. F.; Eren, A. Ay; Yucel, B.; Elagoz, S.; Ozguven, Y.; Altun, A.; Kilickap, S.[Abstract Not Available]Öğe Melatonin: therapeutic and clinical utilization(Wiley, 2007) Altun, A.; Ugur-Altun, B.Melatonin, acting through melatonin receptors, is involved in numerous physiological processes including circadian entrainment, blood pressure regulation, oncogenesis, retinal physiology, seasonal reproduction, ovarian physiology, immune function and most recently in inducing osteoblast differentiation. Moreover, melatonin was proved to be a potent-free radical scavenger and a broad-spectrum antioxidant. More research is required into the effects of therapeutically modulating the melatoninergic system on circadian haemodynamics and rhythm under varying physiopathological conditions and the possible impact on morbidity and mortality in humans.Öğe PERICARDITIS RELATED THROMBOTIC THROMBOCYTOPENIC PURPURA(Elsevier Ireland Ltd, 2011) Barutcu, A.; Aktoz, M.; Altun, A.; Alicik, G.[Abstract Not Available]Öğe Pulmonary microvascular permeability and gas exchange in patients with syndrome X(Lithographia, 2012) Durmus-Altun, G.; Vardar, S. A.; Salihoglu, Y. S.; Aktoz, M.; Dirlik, B.; Altun, A.Aim: This clinical study was planned to assess pulmonary microvascular permeability in patients with Syndrome X (SX) by using a functional imaging tool, technetium-99m-diethyltriaminepentaaceticacid (Tc-99m-DTPA) lung clearance scintigraphy, and the pulmonary functions test, which includes diffusion capacity of the lung for carbon monoxide (DLCO). Methods: The study population consisted of 22 non-smoker subjects divided into two groups. First group comprised 12 patients (4 male, 8 female, mean age: 48 +/- 4 years, range 36 to 65) with SX. Ten healthy subject (4 men, 6 female, mean age: 45 +/- 3 years, range 34 to 58) were served as control group. Volumetric pulmonary functions, including DLCO were also performed before lung scintigraphy. Alveolar epithelial permeability was assessed by measuring the pulmonary clearance of an inhaled Tc-99m-DTPA using a gamma camera. Results: Spirometric data was comparable in both groups. Although volumetric pulmonary measurements were similar, DLCO values of SX patients were lower than those in control (20.9 +/- 1.7 ml/min/mmHg vs. 27.8 +/- 1.3 ml/min/mmHg, p=0.002). The mean clearance rate of Tc-99m-DTPA in control subjects was 106 +/- 6 min, and this value was lower than patients with SX (179 +/- 19 min; p=0.0001). Conclusion: We conclude that lung is a target organ for SX. The pulmonary gas exchange and microvascular permeability, which is measured by 99mTc-DTPA scintigraphy, are restricted without change of volumetric pulmonary functions in patients with SX. Hippokratia 2012; 16 (2): 113-117Öğe A retrospective study of angiographically determined anomalous coronary arteries in 12,844 subjects in Thrace region of Turkey(Lithographia, 2012) Sivri, N.; Aktoz, M.; Yalta, K.; Ozcelik, F.; Altun, A.Background: Congenital anomalies of the coronary arteries are rarely encountered in patients undergoing cardiac catheterization. In patients undergoing coronary angioplasty or cardiac surgery, angiographic recognition of coronary anomalies is important for the proper management of these patients. Method: We retrospectively reviewed the records of 12,844 patients who had previously undergone coronary angiography in the catheterization laboratory of Trakya University Cardiology Department over the past 14 years. We tried to investigate the presence of a variety of coronary anomalies in these patients to determine the prevalence of various types of anomalies and their anatomic variation in a selected population of the European part of Turkey. The potential association between coronary atherosclerosis and congenital coronary anomalies was also investigated. Results: Among these patients, 95 patients were found to have major coronary anomalies that predominantly comprised anomalous aortic origin of coronary arteries. Among the major anomalies, anomalous aortic origin of the left circumflex (LCX) artery from the right sinus of Valsalva or right coronary artery (RCA) was found to be the the most prevalent (46 out of 95 patients) outnumbering the second most common anomaly that was anomalous aortic origin of the RCA (32 out of 95 patients). In the present study, the incidence of major coronary arterial anomaly was found to be 0.74 %. However, only about one third of the patients (31 out of 95, 32.6%) with major anomaly had significant coronary atherosclerotic lesions among whom nine were found to involve the LCX artery with a posterior course. Conclusion: The incidence of congenital coronary anomalies in a selected population of the European part of Turkey is similar to those of other populations. Congenital coronary anomalies generally present as isolated anomalies and are not associated with an increased risk of coronary atherosclerosis in this series. Cardiologists and surgeons should be familiar with these entities for the proper management of patients undergoing cardiac surgery or coronary angioplasty. Hippokratia 2012; 16 (3): 2246-249Öğe An unusual but dramatic complication of coronary angiography: Transient cortical blindness(Elsevier Ireland Ltd, 2007) Tatli, E.; Buyuklu, M.; Altun, A.A 52-year-old woman developed transient cortical blindness after coronary angiography. Its occurrence after coronary angiography is far less common. A possible mechanism of this complication may be contrast penetration of the blood-brain barrier with direct neurotoxicity to the occipital cortex. Patient outcome is excellent, with complete recovery expected within 24-48 h. (c) 2007 Published by Elsevier Ireland Ltd.Öğe THE VALUE OF BNP LEVELS IN THE DIAGNOSIS OF CLINICAL RIGHT VENTRICULAR DYSFUNCTION RELATED WITH ACUTE INFERIOR MYOCARDIAL INFARCTION(Elsevier Ireland Ltd, 2011) Yildirim, T.; Yildirim, S. E.; Aktoz, M.; Altun, A.[Abstract Not Available]
