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    CHARACTERISTICS AND SURVIVAL DATA OF PATIENTS WITH PRIMARY FOCAL SEGMENTAL SEGMENTAL GLOMERULOSCLEROSIS: TSN-GOLDMULTI-CENTER STUDY
    (Oxford Univ Press, 2023) Dheir, Hamad; Cebeci, Egemen; Karadag, Serhat; Yildiz, Abdulmecit; Guller, Nurana; Altiparmak, Mehmet Riza; Eren, Necmi
    [Abstract Not Available]
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    Could mesangial C3 deposition be an independent prognostic marker in immunoglobulin A nephropathy?
    (Springer Heidelberg, 2023) Cetinkaya, Hakki; Gursu, Meltem; Yazici, Halil; Cebeci, Egemen; Eren, Necmi; Altiparmak, Mehmet Riza; Akcay, Omer Faruk
    Background: Immunoglobulin A nephropathy (IgAN) is a common primary glomerulonephropathy. There is evidence that mesangial C3 deposition plays a role in the development of the disease. The aim of this study was to examine the effect of C3 deposition on the prognosis of IgAN patients.Method: The study included 1135 patients with biopsy-confirmed IgAN from the database of the Turkish Nephrology Association Glomerular Diseases Working Group (TSN-GOLD). Patients were excluded from the study if they were aged < 18 or > 75 years or if C3 staining had not been performed in the immunofluorescent analysis. C3 deposition was defined as an immunofluorescence intensity of C3 >= 2 + within the mesangium. The primary endpoints were the development of end-stage renal disease, a 30% decrease in glomerular filtration rate compared to the basal value or an elevation in proteinuria to a nephrotic level (3.5 gr/day).Results: Mesangial C3 deposition was observed in 603 (53.1%) patients. No statistically significant difference was found at baseline between the groups with and without mesangial C3 deposition, as for age, sex, BMI, proteinuria level, or the presence of hypertension. In the follow-up period with a mean duration of 78 months, no significant difference was found between the two groups regarding the primary endpoints (p = 0.43). A significant correlation between C3 deposition and segmental glomerulosclerosis (S1) according to the Oxford MEST-C classification was found (p = 0.001).Conclusion: Although a correlation was observed between mesangial C3 deposition and the S1 MEST-C classification, mesangial C3 deposition was not a prognostic factor in IgAN.
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    COULD MESANGIAL C3 DEPOSITION BE AN INDEPENDENT PROGNOSTIC MARKER IN IMMUNOGLOBULIN A NEPHROPATHY?
    (Oxford Univ Press, 2023) Cetinkaya, Hakki; Gursu, Meltem; Yazici, Halil; Cebeci, Egemen; Eren, Necmi; Altiparmak, Mehmet Riza; Akcay, Omer Faruk
    [Abstract Not Available]
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    Frequency of gallstones after renal transplantation and factors that affect gallstone formation
    (John Wiley & Sons Inc, 2007) Celik, Aykut Ferhat; Altiparmak, Mehmet Riza; Pamuk, Guelsuem Emel; Pamuk, Oemer Nuri; Apaydin, Sueheyla
    BACKGROUND: We investigated the frequency of gallstones (GSs) in our renal transplant recipients and evaluated the effects of various factors on GS formation. METHODS: One hundred and eight-two patients who had undergone renal transplantation at our center in the last 12 years were included in the study. Of these, 163 patients were followed up regularly, of whom 118 were using cyclosporine A (CsA). Abdominal ultrasonography of all patients was performed, and biochemical parameters were also determined. RESULTS: Median duration of patient follow-up was 36 months. GSs were diagnosed in 5 patients (3.1%). Mean age and follow-up duration of the CsA group were lower than those of the non-CsA group (p < 0.05 and p < 0.001, respectively). The frequency of GSs was 3.4% in the CsA group and 2.2% in the non-CsA group (p > 0.05). Median time to detect GS formation in the post-transplantation period was 85 months. The CsA group had a significantly shorter GS-free follow-up period than the non-CsA group (p = 0.008). According to Cox multivariate regression analysis, the only factor that affected GS formation in the post-transplantation period was the use of CsA. CONCLUSION: The use of CsA showed a trend toward increasing the risk of developing a GS sooner in the post-transplant period, particularly for young men.