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    The importance of serum total and lipid-bound sialic acid as markers in patients with small cell and non-small cell lung carcinoma
    (Aves Yayincilik, Ibrahim Kara, 2007) Gokmen, Selma Suer; Kazezoglu, Cemal; Tabakoglu, Erhan; Altiay, Guendeniz; Gungoer, Ozgul; Ture, Mevlut
    Objectives: Serum total sialic acid (TSA) and lipid-bound sialic acid (LSA) levels were investigated in patients with small and non-small cell lung carcinoma and their role in discriminating small from non-small cell lung carcinoma and lung carcinoma from healthy individuals was evaluated. Patients and Methods: The study included 159 male patients with non-small cell lung carcinoma (n=102) and small cell lung carcinoma (n=57) who never received chemotherapy and/or radiotherapy and 35 healthy volunteers as controls. Serum TSA and LSA levels were determined by the methods of Warren and Katopodis, respectively. Results: Serum TSA and LSA levels in both patient groups were significantly elevated when compared with controls (p < 0.001), but the patient groups did not differ significantly in this respect. Receiver operating characteristic (ROC) analysis showed that TSA was more specific and LSA was more sensitive in distinguishing patients with non-small cell carcinoma from healthy individuals. On the other hand, LSA was found to be more sensitive in distinguishing patients with small cell carcinoma from healthy controls. Conclusion: Serum total and lipid-bound sialic acid may play an important role as biochemical markers in distinguishing patients with small and non-small cell lung carcinoma from healthy subjects.
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    A retrospective evaluation of patients with sleep breathing disorders in single center, Edirne province
    (Turkish Assoc Tuberculosis & Thorax, 2023) Korucuoglu, Cemile; Yilmam, Ilker; Yildiz, Ethem; Altiay, Guendeniz
    Introduction: Our aim was to investigate the characteristics of patients with preliminary diagnosis of sleep breathing disorder studied in Edirne province, to identify the risk factors and comorbid conditions, to determine the diagnostic distribution of our sleep patients by analyzing the results of polysomnogra-phy and PAP titration, and to understand their problems related to treatment compliance and device use.Materials and Methods: Our study retrospectively evaluated the results of 956 patients who had sleep-related complaints in our region and underwent full nocturnal polysomnography and PAP titration with a preliminary diagnosis of sleep breathing disorder.Results: A total of 956 patients were enrolled in the study, of whom 641 (67.1%) were males and 315 (32.9%) were females. Of our patients, 49.7% had severe obstructive sleep apnea (OSA), 18.2% had moderate OSA, 17.9% had mild OSA, 11.4% had REM-dependent OSA, and 8.4% had position -supine-dependent OSA. Hypertension was the most common comorbid condition in 44% of our patients, and diabetes mellitus in 25%. It was deter-mined that 228 (57.9%) of 394 patients who were recommended to use the PAP device received the device, and 71.5% of these patients could use the device in a compatible manner.Conclusion: Patients with appropriate symptoms can be diagnosed with a high probability of OSA in our region. The fact that a substantial group of patients diagnosed with OSA and recommended to use the PAP device did not receive the device or the proportion of those who could not use the device was high is one of the notable findings of the study.
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    Skin prick test results in patients from Thrace region presenting with pulmonary symptoms
    (Aves Yayincilik, Ibrahim Kara, 2007) Edis, Ebru Cakir; Tabakoglu, Erhan; Caglar, Tuncay; Hatipoglu, Osman N.; Altiay, Guendeniz
    Objectives: The aim of the study was to determine the profile of allergen sensitization in patients presenting with pulmonary symptoms. Patients and Methods: Skin test results of 196 patients (136 females, 60 males; mean age 34.7 +/- 11.7 years) presenting with pulmonary complaints between October 1999 and April 2005; total IgE results and allergy information forms were analyzed retrospectively. Results: Median value of IgE was (%25-75) 202 U/ml (118-530) in the patients enrolled. The most frequent symptom was shortness of breath (65.3%), and the second was cough (63.8%). These symptoms aggravated while patients were dusting. Sensitivity to at least one allergen was observed in 59.7% of the patients. Sensitivity to a single allergen was present in 18.9% and to multiple allergens in 40.8% of all patients. The most frequent allergy was determined to house dust mite (39.8%) and was followed by allergy to tree pollens (26%). Sensitivity rate to D. Farinea was 33.7% and 32.7% to D. Pteronyssinus. Conclusion: House dust mite were the primary causes of sensitization in patients presenting with allergic symptoms in the Thrace region. The fact that the symptoms aggravated in 46.9% of the patients while they were dusting at home, seemed to support this finding.
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    Socioeconomic features and predisposing factors in patients with bronchiectasis
    (Aves Yayincilik, Ibrahim Kara, 2007) Ozdemir, Levent; Tabakoglu, Erhan; Hatipoglu, Osman Nuri; Altiay, Guendeniz; Ozlen, Burcu; Ciftci, Abdullah; Caglar, Tuncay
    Objectives: The aim of this study was to determine socioeconomic features of cases with bronchiectasis and to determine predisposing factors which might play a role in the development of this condition. Patients and Methods: A total of 69 cases with bronchiectasis (43 males, 26 females; mean age 53.7 +/- 15.6 years) were retrospectively evaluated. Patients, totally in whom the was, predisposing factors for bronchiectasis, cigarette and alcohol consumptions, education and and monthly income levels were recorded. Results: Most of the cases multiple predisposing factors for bronchiectasis. Pneumonia (68%), measles (32%), and tuberculosis (18%) were the most common causes. Forty-two percent of the cases were primary school graduates and 20% never attended school. Fifty-five percent of the cases smoked cigarettes and 19% of the cases used alcohol. The mean monthly income was found to be 438.2 +/- 363 YTL. Conclusion: We concluded that bronchiectasis is prominent among individuals with low socioeconomic level.