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    Assessment of Tc-99m sestamibi tumor tissue uptake under the influence of increased arterial oxygen saturation
    (Elsevier Science Inc, 2005) Cermik, TF; Altiay, G; Firat, MF; Hatipoglu, ON; Berkarda, S
    The aim of this study is to investigate the potential effect of increased arterial saturation of oxygen in the magnitude of technetium-99m-hexakis-isobutyl-isonitrile ((99)mTc-MIBI) uptake in tumor tissue and to compare the results with those of conventional Tc-99m-MIBI tumor imaging in the same patient with lung cancer. A total of 26 lung cancer patients underwent initial SPECT (I-SPECT) and after oxygen inhalation SPECT (O-2-SPECT). The early (ER) and delayed ratios (DR) Of O-2-SPECT mean +/- S.D. were significantly higher than those of I-SPECT mean +/- S.D. (2.07 +/- 0.57 vs. 1.90 +/- 0.48 and 2.02 +/- 0.45 vs. 1.83 +/- 0.39, respectively). There are increased rates for the relative tumor uptake of Tc-99m-MIBI by 9% for ER and 10% for DR on the O-2-SPECT compared to I-SPECT. We found that 99mTc-MIBI uptake increased significantly in the tumor tissue with O-2-SPECT compared to I-SPECT. In conclusion, 99mTc-MIBI scintigraphy is one of the main methods for differentiating viable and nonviable tissue fractions in tumors. We consider that 99mTc-MIBI uptake increase after oxygen inhalation is an indicator of positive acute cellular response of the tumor tissue to the rising tissue oxygen level. (c) 2005 Elsevier Inc. All rights reserved.
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    Clearance of technetium-99m-labeled DTPA in hyperthyroidism without clinical evidence of lung disease, and relation to pulmonary function
    (Springer, 2005) Guldiken, S; Tugrul, A; Altiay, G; Hacimahmutoglu, S; Durmus-Altun, G
    Objective: The mechanisms of dyspnea and exercise intolerance have not been fully elucidated. We aimed to investigate the clearance rate of technetium-99m diethyltriaminepentaaceticacid (Tc-99m DTPA) from lungs in hyperthyroid patients without clinical evidence of lung disease and to explore the interactions between their Tc-99m DTPA radioaerosol lung scintigraphy, spirometric measurements, and the levels of thyroid hormones. Methods: We studied 19 hyperthyroid patients and 16 sex- and age-matched controls. Thyroid hormone levels were assessed. Spirometric lung function tests, diffusing capacity of the lung for carbon monoxide (DLCO) and the clearance rate of Tc-99m DTPA were performed in all participants. Ratio of DLCO value to the alveolar ventilation (DLCO/VA) and the means of half-time (T-1/2) of Tc-99m DTPA clearance rate, which were used to evaluate alveolar-capillary membrane permeability, were calculated. Results: There were no statistical differences between spirometfic parameters (VC, FVC, FEV1/FVC, FEF 25-75) of the two groups (p > 0.05). Although the mean FEV1 level was significantly lower in the hyperthyroid patients than the control subjects (p < 0.01), in five patients FEV1 was only less than 80 percent of the predicted value. No significant difference in the means of DLCO, DLCO/VA or T-1/2 values of Tc-99m DTPA clearance was observed between the two groups (p > 0.05). In hyperthyroid patients, there was a positive relation between DLCO/VA, DLCO/VA % and T-1/2 values of Tc-99m DTPA clearance (p < 0.01, r = 0.732, p < 0.01, r = 0.742, respectively). The lung volumes and the levels of thyroid hormones did not show a significant relationship to T-1/2 values of Tc-99m DTPA clearance in hyperthyroid group (p > 0.05). Conclusions: We conclude that increased thyroid hormones have no effect on permeability of alveolar-capillary membrane in hyperthyroid patients.
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    Levels of superoxide dismutase and malondialdehyde in primary spontaneous pneumothorax
    (Carfax Publishing, 2004) Tabakoglu, E; Ciftci, S; Hatipoglu, ON; Altiay, G; Caglar, T
    THE aim of the present study is to determine whether patients with primary spontaneous pneumothorax (PSP) are subject to oxidative stress. For this purpose, we measured the activities of red blood cell superoxide dismutase, which is an antioxidant enzyme, and the level of plasma malondialdehyde, which is one of the lipid peroxidation markers, in a group of patients with PSP. The study was carried out with 16 patients with PSP and 24 healthy individuals. The two groups were similar to each other in terms of sex, age and smoking attitudes. Erythrocyte superoxide dismutase activity was found to be significantly lower in patients with PSP than in the control group (p < 0.01). The plasma malondialdehyde levels were significantly high in patients with PSP (p < 0.01). Our results suggest that oxidative stress may contribute to the pathogenesis of PSP.