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Öğe An analysis of genetic transmission in a father and son with osteosarcoma(2006) Tokatli F.; Alas R.C.; Altaner S.; Pala F.; Uygun K.; Uzal C.; Yalniz E.Familial osteosarcoma is a rare hereditary disease. We present a 37-year-old father and a 17-year-old son who developed osteosarcoma in the left and right distal femurs, respectively, at a three-year interval. They were treated with chemotherapy followed by surgery. Both had positive immunostaining for p53 tumor suppressor gene and HER-2/neu oncogene. The son also exhibited deletion of the retinoblastoma 1 gene. Pulmonary metastasis was detected in the father at the time of diagnosis and 13 months after primary treatment, whereas no distant metastasis was present in the child. The father died 39 months after the diagnosis from primary symptoms, but the son led a disease-free survival a year after completion of treatment. Genetic abnormalities documented in the father and son corroborate the presence of specific genetic alterations in the pathogenesis of osteosarcoma.Öğe A case of epithelial-myoepithelial carcinoma of the parotid gland.(2003) Taş A.; Yagiz R.; Altaner S.; Koten M.; Karasalihoglu A.R.Epithelial-myoepithelial carcinomas comprise approximately 1% of all salivary gland neoplasms. Most tumors arise in the major salivary glands, especially in the parotid gland. We present a case of epithelial-myoepithelial carcinoma of the parotid gland in a 65-year-old male patient. Magnetic resonance imaging showed an irregular and heterogeneous mass in the left parotid gland. Superficial parotidectomy was performed. There was no evidence of recurrence during a 21-month follow-up.Öğe Epithelial-myoepithelial carcinoma of the lung. A case report and review of the literature.(2003) Doganay L.; Bilgi S.; Ozdil A.; Yoruk Y.; Altaner S.; Kutlu K.Primary lung tumors mimicking the salivary gland-type neoplasms are extremely rare. These types of tumors originate from submucosal bronchial glands. Epithelial-myoepithelial carcinoma is an uncommon tumor in this group, and only 7 cases have been reported. It is considered to be a low-grade malignant neoplasm. We report a case of epithelial-myoepithelial carcinoma of bronchial gland origin in a 73-year-old man who presented with coughing and dyspnea. The bronchus of the left lower lobe contained a tumor mass that had a polypoid growth pattern. The tumor also extended into the pulmonary parenchyma, forming a well-circumscribed mass with a pushing margin. The tumor consisted of epithelial and myoepithelial cells. The epithelial cells were positive for cytokeratins and epithelial membrane antigen, while the myoepithelial cells were positive for S100 protein and muscle-specific actin. According to these findings, we diagnosed epithelial-myoepithelial carcinoma. After undergoing pneumonectomy, the patient has been disease free for 34 months.Öğe Expression of the cyclin-dependent kinase inhibitor p27 in transitional cell bladder cancers: Is it a good predictor for tumor behavior?(2003) Doganay L.; Altaner S.; Bilgi S.; Kaya E.; Ekuklu G.; Kutlu K.Objectives: Progression of the cell cycle is regulated by the interactions of cyclins, cyclin dependent kinases (CDKs) and CDK inhibitors (CDKIs). p27 is a member of the universal cyclin-dependent kinase inhibitor family. The level of p27 protein expression decreases during tumor development and progression in some epithelial, lymphoid and endocrine tissues. It has been suggested that p27 is an independent prognostic factor in various human cancers. The prognostic value of p27 protein expression is not completely understood in bladder cancer yet. Aims: To investigate the immunohistochemical expression of p27 in transitional cell bladder cancers and its relationship with clinicopathological data, proliferating cell nuclear antigen (PCNA) and p53 oncoprotein immunoreactivity. Methods: The expression of p27 protein was immunohistochemically analyzed in paraffin-embedded specimens of 75 patients with transitional cell carcinoma of the bladder. p27 expression was compared with tumor grade, stage, growth pattern, disease-free survival, progression, PCNA and p53 immunoreactivity. Results: Expression of p27 was not significantly related to clinicopathologic parameters, disease-free survival, progression, PCNA and p53 immunoreactivity. Conclusion: The results indicate that p27 is not a good predictor for outcome of transitional cell carcinoma of the bladder. © 2004 Kluwer Academic Publishers.Öğe Gastroprotective effect of L-carnitine on indomethacin-induced gastric mucosal injury in rats: a preliminary study.(2006) Erkin B.; Dokmeci D.; Altaner S.; Turan F.N.BACKGROUND: Numerous studies have shown that use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with various gastric mucosal lesions, collectively referred to as NSAID gastropathy, but the detailed mechanism is still not properly understood. L-carnitine, a vitamin-like substance, is a naturally occurring enzymatic antioxidant with a potent free oxygen radical quencher and scavenger capacity; it protects the biological membranes against lipid peroxidation. It has recently been shown that L-carnitine has a gastroprotective effect on gastric mucosa. To our knowledge, the role of L-carnitine on NSAIDs-induced gastric mucosal injury is undefined. AIM: The aim of the present study was to determine the gastroprotective effect of L-carnitine on indomethacin-induced gastric mucosal lesions in the rat stomachs. MATERIAL AND METHODS: In our study, gastric mucosal injury was induced by the intragastric administration of indomethacin (30 mg/kg). L-carnitine (10, 50, 100 mg/kg) was given to rats by gavage 30 min before the indomethacin administration. The animals were killed 3 h after administration of indomethacin. The stomach of each animal was removed. Mucosal damage was evaluated with macroscopic study and histopathologically. RESULTS: The intragastric administration of indomethacin induced hyperemia and hemorrhagic erosions in the rat stomachs. L-carnitine significantly prevented gastric ulcerogenesis induced by indomethacin and decreased the ulcer index macroscopically and histopathologically. CONCLUSION: L-carnitine decreases indomethacin-induced gastric mucosal injury and this gastroprotective effect may be attributed to its well-known antioxidant effect.Öğe Gorham-Stout disease of the humerus(2008) Yalniz E.; Alicioglu B.; Benlier E.; Yilmaz B.; Altaner S.Gorham-Stout disease is characterized by local proliferation of small vascular or lymphatic channels resulting in progressive destruction and resorption of bone. The etiology and pathogenesis of the disease remains mostly unknown, despite some 175 reported cases. A case of Gorham-Stout disease of the humerus in a 14-year-old boy is described. The patient presented with progressive pain and deformity of the right arm. Although the disease was described in different bones of the body its location in the humerus is rare. We report the natural history and clinical follow-up in a young patient. A fibular graft was performed but 10 months later, resorption and pathological fractures occurred again. This study presents the radiographic and MRI features of Gorham disease.Öğe Histopathologic examination of the effects of cyclosporin A alone and the combined therapy with prednisolone on lung: An experimental study(Cambridge University Press, 2003) Aktas R.G.; Altaner S.; Guven A.; Coskun O.; Barut C.; Ozen O.A.[No abstract available]Öğe Lymphoepithelioma-like carcinoma of the urinary bladder: A case report and discussion of differential diagnosis(2005) Guresci S.; Doganay L.; Altaner S.; Atakan H.I.; Kutlu K.Lymphoepithelioma-like carcinoma (LELC) of the urinary bladder is very rare. It is mandatory to make differential diagnosis among lymphoma, chronic cystitis and LELC because of different therapeutic approach. A bladder tumor was found in a 90-year-old patient suffering from hematuria. After transurethral resection, undifferentiated tumor with prominent lymphoid infiltration was seen on light microscopy. Immunohistochemical examination demonstrated positive staining of tumor cells with cytokeratin (CK), epithelial membrane antigen and CK-20. We presented the case because of its rarity and related literature was reviewed. © Springer 2005.Öğe Nontraumatic giant fat necrosis of the breast presenting as a rapidly growing tumor.(2011) Tuncbilek N.; Sezer A.; Altaner S.; Mentes A.; Mercangül D.; Durmus Y.; Temizöz O.Nontraumatic rapid growing giant fat necrosis of the breast mimicking breast tumors is a rare clinical manifestation. The imaging features of the fat necrosis which range from benign to malign findings may be better explained with associated aetiology. The present paper reports a 54-year old woman with a rapid growing, fibrous, and hard giant mass originating in the subareolar region of the left breast. Mammography and magnetic resonance imaging demonstrated a heterogeneous, well circumscribed mass in 12 × 12 cm size in the left breast. The lesion was suspected as a malignant tumor and underwent core biopsy. The histopathology examination of the biopsy revealed mononuclear cells, foamy, vacuolated, and bubbly cells containing fat. Excision biopsy of the mass was performed and the final pathological diagnosis was confirmed as fat necrosis. The wide clinical and radiologic manifestations of fat necrosis are still difficult to diagnose even with the new diagnostic modalities and a great proportion of these lesions need a biopsy to diagnose.Öğe Papillary carcinoma arising from a thyroglossal duct cyst(2007) Ya?iz R.; Taş A.; Altaner S.; Karasaliho?lu A.Thyroglossal duct cyst is the most common midline congenital neck anomaly. Carcinoma arising from a thyroglossal duct cyst is a rare entity, the most common histological type being papillary carcinoma. A 23-year-old male patient presented with a painless mass at the level of the hyoid bone in the midline of the neck. It was mobile on swallowing. With an initial diagnosis of thyroglossal duct cyst, the lesion was removed with the Sistrunk procedure. Histopathological examination of the surgical specimen showed papillary carcinoma arising from the thyroglossal duct cyst. Thyroid suppression therapy was initiated postoperatively. The patient has been under follow-up for 30 months with no recurrence.Öğe Prevention of cyclophosphamide-induced ovarian damage by concomitant administration of GnRHa in mice: A dose-dependent relationship?(2004) Yüce M.A.; Balkani Kaplan P.; Gücer F.; Do?anay L.; Altaner S.; Canda T.; Yardim T.Objective (s): This experimental study investigates the dose-related effects of cyclophosphamide (Cy) on primordial follicular reserve in young mice, and examines whether the concomitant administration of a gonadotropin-releasing hormone agonist (GnRHa) may protect gonadal reserve, even at different doses of Cy. Methods: Forty sexually mature virginal Balb/c mice aged five to six weeks were administered different doses (0, 50, 75,100 mg/kg) of Cy. Another 40 animals were treated with increasing doses (0, 50, 75, 100 mg/kg) of Cy in combination with GnRHa. GnRHa treatment was initiated one week prior to chemotherapy and also continued after chemotherapy for one week. The ovaries were removed seven days after Cy administration and the total number of primordial follicles in both ovaries was counted. Results: Primordial follicular destruction occurred at all levels of Cy exposure. There was a positive correlation between increasing doses of Cy and higher proportion of follicular loss (p < 0.0001). GnRHa was not able to protect against the chemotherapy-induced negative effect on primordial follicular count at low doses (50 mg/kg and 75 mg/kg). Mean ± SD primordial follicle count in the 100 mg/kg Cy-treated group was significantly lower than in the 100 mg/kg Cy + GnRHa treatment group (73.9 ± 33.1 vs 89 ± 17.9, p = 0.047). Conclusion: Our data suggest a possible ovarian protective effect of GnRHa cotreatment only at high doses of Cy treatment. However, in spite of co-administration of GnRHa, loss of primordial follicular reserve occurred at all doses of Cy in mice.Öğe Pure nongestational choriocarcinoma of the ovary in a child: Case report(2009) Altaner S.; Taştekin E.; Aksu B.; Öz Puyan F.; Kutlu K.A 9-year-old girl was admitted to our hospital with abdominal pain and distention due to a complex ovarian mass. An ultrasound scan showed a 7×5×5 cm, intensive fluid loculation and septation in right inferior quadran pericheacecal area. Radiologist reported this massas an abscess formation. The laboratory data showed high serum level of HCG. The level of FSH, estrodiol, LH, total testesteron, androstenodion, CEA, AFP ve 17-OH progesteron were normal. An emergency surgery was planned with these findings. Right salpingoophorectomy, and left ovary wedge resection and lymph node dissection were performed. The right ovary revealed a cystic, necrosis and hemorrhagic tumor with solid parts. The microscopic examination containing wide areas of necrosis and hemorrhagic in which atypical cytotrophoblastic and syncitiotrophoblastic cells are observed. Syncitiotrophoblastic cells was immunohistochemically diffuse positive for HCG. Furthermore, It was focally positive for inhibin and diffuse positive for keratin. CD99, CD30, CEA, NSE, PLAP, AFP were negative. We present a case of a 9-year-old girl diagnosed with pure nongestational choriocarcinoma of the ovary with a review of the literature.
