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Öğe Acute radiation effect in the brain in infant rats: Neurocognitive and histopathological examination(Imprimatur Publications, 2011) Gorker, I.; Yurut-Caloglu, V.; Karadag, H.; Caloglu, M.; Altaner, S.; Cengiz, H.; Ozen, A.Purpose: The aim of the present study was to evaluate the radiation-induced cognitive dysfunction and the radioprotective effect of amifostine (AMI) in the brain of infantile rats. Methods: Thirty 2-week-old rats were randomly assigned into 3 groups of 10 rats each. Group 1 : control (CONT), group 2: radiation alone (RT), and group 3: AMI before radiation (AMI+RT). The rats in the RT and AMI+RT groups were irradiated individually with a single dose of 20 Gy. All animals were evaluated by using the Morris water maze test to evaluate of their cognitive functions. Histopathological analyses of the hippocampus were also carried out after euthanasia. Results: The study showed that the place navigational function and the spatial probe test were not significantly different between the groups. Conclusion: It can be said that it is very important to determine when the radiation-induced brain injury is formed. From a clinical perspective, the patients can be intervened before irreversible functional deficits are formed and may be amenable to treatment.Öğe Analysis of relationship between dynamic MRI parameters with prognostic factors and survival in breast cancer patients(Elsevier Ireland Ltd, 2006) Tuncbilek, N.; Tokatli, F.; Okten, O.; Altaner, S.[Abstract Not Available]Öğe Comparison of dynamic contrast-enhanced MRI parameters with 99mTc-sestamibi uptake ratios in malignant bone and soft-tissue tumours.(Springer, 2009) Sarikaya, A.; Tuncbilek, N.; Altaner, S.; Torun, N.; Korkmaz, U.; Yalniz, E.[Abstract Not Available]Öğe Comparison of Tc99m Tetrofosmin scintigraphy, Doppler sonography and Microvessel Density As Assessment of tumor angiogenesis after morphine administration(Springer, 2008) Ustun, F.; Durmus-Altun, G.; Tuncbilek, N.; Altaner, S.; Uzal, C.; Berkarda, S.[Abstract Not Available]Öğe GORHAM-STOUT DISEASE OF THE HUMERUS(Assoc Royal Soc Scientifiques Medicales Belges, 2008) Yalniz, E.; Alicioglu, B.; Benlier, E.; Yilmaz, B.; Altaner, S.Gorham-Stout disease is characterized by local proliferation of small vascular or lymphatic channels resulting in progressive destruction and resorption of bone. The etiology and pathogenesis of the disease remains mostly unknown, despite some 175 reported cases. A case of Gorham-Stout disease of the humerus in a 14-year-old boy is described. The patient presented with progressive pain and deformity of the right arm. Although the disease was described in different bones of the body its location in the humerus is rare. We report the natural history and clinical follow-up in a young patient. A fibular graft was performed but 10 months later, resorption and pathological fractures occurred again. This study presents the radiographic and MRI features of Gorham disease.Öğe The histopathologic comparison of the protective effects of L-Carnitine and amifostine against high-dose radioiodine therapy -induced lacrimal gland damage in the guinea pig(Springer, 2009) Durmus-Altun, G.; Ozdil-Muratli, A.; Torun, N.; Ergulen, A.; Ustun, F.; Altaner, S.[Abstract Not Available]Öğe Light and Electron Microscopic Examination of The Effects of Long Term-Low Dose CyclosporinA (CsA) and Its Combination with Prednisolone on Hematopoietic Cells(Amer Soc Cell Biology, 2011) Aktas, R. G.; Ercan, F.; Altaner, S.[Abstract Not Available]Öğe Scintigraphic evaluation of small intestinal transit in the streptozotocin induced diabetic rats(Lithographia, 2011) Durmus-Altun, G.; Vatansever, U.; Arzu, Vardar S.; Altaner, S.; Dirlik, B.Aim: Small intestine (SI) transit in the streptozotocin (STZ) induced diabetic rats were examined by using 99mTc-mebrofenin scintigraphy. Materials and methods: Wistar albino rats (mean body weight: 220 +/- 12 g) were studied for both control (n=10) and diabetes mellitus (DM) (n=10) groups. Diabetes was induced by a single intraperitoneal injection of streptozotocin (50 mg kg(-1) body weight. SI transit time was assessed by measuring arrival times of 99mTc-mebrofenin from duodenum to caecum. Results: The mean transit time of 99mTc-mebrofenin was 67.8 +/- 11 min in control group. The mean transit time of SI was prolonged in STZ induced diabetic animals with (111.9 +/- 12.5, p=0.01). There was significant correlation between small intestinal transit time and blood glucose level (r: 0.73, p=0.01). Conclusion: We observed that SI transit was prolonged in diabetic animals using 99mTc-mebrofenin, and additionally this technique is a readily available method for the detection of transit abnormalities in animal experiment. Hippokratia 2011; 15 (3): 262-264
