Yazar "Aktas, C." seçeneğine göre listele
Listeleniyor 1 - 3 / 3
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Protective effects of quercetin on testicular torsion/detorsion-induced ischaemia-reperfusion injury in rats(Wiley-Blackwell, 2010) Aktoz, T.; Kanter, M.; Aktas, C.P>The aim of this study was to investigate the protective effect of quercetin (QE) on testicular torsion/detorsion-induced ischaemia-reperfusion (I/R) injury. A total of 24 male Wistar albino rats were divided into three groups: control, I/R and I/R treated with QE; each group contain eight animals. Testicular torsion was created by rotating the left testis 720 degrees in a clockwise direction. The ischaemia period was 5 h and orchiectomy was performed after 5 h of detorsion. QE (15 mg kg-1, i.p.) was administrated only once, 40 min prior to detorsion. Left orchiectomy was performed in all I/R groups. To date, no histopathological changes on testicular torsion/detorsion-induced I/R injury in rats by QE treatment have been reported. Spermatogenesis and mean seminiferous tubule diameter were significantly decreased in I/R groups were compared with the control group. Furthermore, QE treated animals showed an improved histological appearance in I/R group. Our data indicate a significant reduction in the activity of TUNEL, endothelial nitric oxide synthase and a rise in the expression of testosterone in testes tissue of I/R treated with QE therapy. We believe that further preclinical research into the utility of QE may indicate its usefulness as a potential treatment on testes injury after I/R in rats.Öğe Protective effects of Urtica dioica L. on experimental testicular ischaemia reperfusion injury in rats(Wiley, 2017) Aktas, C.; Erboga, M.; Erboga, Z. Fidanol; Donmez, Y. Bozdemir; Topcu, B.; Gurel, A.In this study, it was aimed to examine the effects of Urtica dioica L. (UD) that has antioxidant feature in the experimental testicular I/R model in rats in terms of anti-apoptotic and antioxidative effects. In our study, 24 male rats were divided into three groups: control group, I/R group and I/R+UD (2mgkg(-1)) group. Seminiferous tubule calibre measurement, Johnson score, haematoxylin-eosin staining, proliferative cell nucleus antigen (PCNA) immunohistochemical staining and TUNEL as histopathological have been conducted. The structural deterioration in the testicular on I/R group has reduced after the treatment of UD. Our data indicate a significant reduction in the activity of in situ identification of apoptosis using terminal dUTP nick end labelling (TUNEL), and there was a rise in the expression of proliferating cell nuclear antigen (PCNA) in testis tissues of UD-treated rats in the I/R group. The I/R+UD group showed a decrease in malondialdehyde levels and an increase in the activities of superoxide dismutase, catalase and glutathione peroxidase in comparison with the I/R group. It could be concluded that protective effects of UD on the I/R testicles are via reduction of histological damage, apoptosis, oxidative stress and lipid peroxidation.Öğe The radioprotective effect of dimethyl sulfoxide in radiation induced acute pulmonary injury: detection by Tc99m-DTPA transalveolar clearance scintigraphy and histopathology(Pergamon-Elsevier Science Ltd, 2009) Denizli, B.; Cosar-Alas, R.; Durmus-Altun, G.; Can, U.; Aktas, C.; Kanter, M.; Parlar, S.[Abstract Not Available]
