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    Acute myocardial infarction shortly after valve-in-valve transcatheter aortic valve implantation successfully managed with challenging percutaneous coronary intervention
    (Turkish Soc Cardiology, 2018) Yalta, Kenan; Kaya, Caglar; Aksoy, Yuksel; Yilmaztepe, Mustafa; Kardas, Fatih
    In recent years, transcatheter aortic valve implantation (TAVI) has been considered a novel option for the management of surgically high-risk patients requiring aortic valve replacement. Presently described is a case of acute coronary syndrome (ACS) managed with a challenging primary percutaneous coronary intervention (PCI) shortly after a valve-in-valve TAVI intervention. This case highlights 2 important issues: PCI may be an option for the management of coronary heart disease in patients after TAVI even in the setting of demanding features associated with coronary osteal engagement, and secondly, TAVI may serve as a potential risk factor for future coronary ischemic syndromes, largely due to its potential adverse effects on coronary flow dynamics, etc. However, the latter notion is quite speculative, and should be tested in further studies.
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    Association of Angiotensin II Type 1 Receptor A1166C Gene Polymorphisms with Coronary Artery Disease in Thrace Region of Turkey
    (Erciyes Univ Sch Medicine, 2021) Taylan, Gokay; Palabiyik, Orkide; Ozkalayci, Flora; Yilmaztepe, Mustafa Adem; Sivri, Nasir; Aksoy, Yuksel
    Objective: Although the risk factors for coronary artery disease (CAD) are well established, a significant gap still exists in understanding the pathology of atherosclerotic heart disease evolving without conventional risk factors. Therefore, genetic factors are considered to play a significant role in this setting. The present study aimed to assess the relationship between angiotensin 2 type 1 receptor (AT1R) A1166C gene polymorphism and CAD. Materials and Methods: Patients with documented CAD (n=121) were compared with controls with normal coronary arteries (n=121). CAD was diagnosed using a coronary angiography. The median age of participants was 59 +/- 12 years with an equal sex distribution. A comparison between the two groups with regard to the AT1R A1166C gene polymorphism was made through the amplification of DNA using polymerase chain reaction. Results: This study demonstrated that adenine-adenine and cytosine-cytosine (CC) genotypes were more frequent, yet adenine-cytosine genotype was less frequent among patients with CAD compared with controls [p=0.003), 95% confidence interval (CI)]. The AT1R A1166C gene polymorphism along with the CC genotype and C allele was found to be associated with CAD. Further, gender, hypertension, family history, age, and low levels of serum high-density lipoprotein also had a significant relationship with AT1R A1166C gene polymorphism. Conclusion: The present study suggested AT1R A1166C gene polymorphism, CC genotype, and C allele as potential risk factors for atherosclerotic CAD. Patients harboring these genetic variants should be under close supervision for the development of CAD.
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    Bone mineral density: A potential determinant of atherosclerotic plaque morphology in established coronary artery disease?
    (Elsevier Ireland Ltd, 2011) Sivri, Nasir; Yalta, Tulin; Yalta, Kenan; Yetkin, Ertan; Aksoy, Yuksel
    [Abstract Not Available]
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    Carotid intima-media thickness:. a new marker of patients with uterine leiomyoma
    (Elsevier, 2014) Aksoy, Yuksel; Sivri, Nasir; Karaoz, Banu; Sayin, Cenk; Yetkin, Ertan
    Objective: To determine whether or not there are any significant differences in carotid intima-media thickness between patients with uterine leiomyoma and controls. Study Design: Patients whose ages were between 40 and 50 years, with body mass index <30 kg/m(2), and with a pathological diagnosis of uterine leiomyoma constituted the study group. Control subjects had no uterine leiomyoma proven by sonography. Demographic, clinical, and drug history data were collected. Right, left and mean carotid intima-media thickness measurements were obtained by ultrasonography. Results: Carotid intima-media thickness and serum high-density lipoprotein (HDL) levels were significantly different between the groups (p = 0.0001 and p = 0.001 respectively), being respectively higher and lower in the leiomyoma group than in controls. Stepwise binary logistic regression analysis revealed that uterine leiomyoma development ratio was 159.32 times higher when carotid intima-media thickness was over 0.61 mm (p = 0.0001). In patients with uterine leiomyoma, carotid intima-media thickness was significantly less in patients taking statins compared to those not on these drugs (p = 0.0001). Conclusion: The present study demonstrated a positive association between carotid intima-media thickness and the presence of uterine leiomyoma. Conversely, an inverse association was suggested between HDL and uterine leiomyoma. These findings suggest that women with uterine leiomyoma might have an increased risk of subclinical atherosclerosis. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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    Chronotropic incompetence: An obscure cause of heart failure symptoms in survivors of critical diseases?
    (Elsevier Ireland Ltd, 2011) Yalta, Kenan; Yalta, Tulin; Sivri, Nasir; Aksoy, Yuksel; Yetkin, Ertan
    [Abstract Not Available]
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    Copeptin (C-terminal provasopressin): A promising marker of arrhythmogenesis in arrhythmia prone subjects?
    (Elsevier Ireland Ltd, 2011) Yalta, Kenan; Sivri, Nasir; Yalta, Tulin; Geyik, Bilal; Aksoy, Yuksel; Yetkin, Ertan
    [Abstract Not Available]
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    Ictal Asystole in a Patient with Right Temporal Lobe Epilepsy
    (Taiwan Soc Cardiology, 2022) Kaya, Caglar; Ozkan, Hulya; Yilmaztepe, Mustafa; Aksoy, Yuksel; Baysal-Kirac, Leyla; Gurses, Candan
    [Abstract Not Available]
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    The impact of a single episode of remote ischemic preconditioning on myocardial injury after elective percutaneous coronary intervention
    (Termedia Publishing House Ltd, 2017) Yilmaztepe, Mustafa A.; Taylan, Gokay; Aktoz, Meryem; Gurlertop, Hanefi Y.; Aksoy, Yuksel; Ozcelik, Fatih; Yalta, Kenan
    Introduction: Myocardial injury after percutaneous coronary intervention (PCI) occurs in approximately 30% of procedures, and is related to worse prognosis. Effects of remote ischemic preconditioning (RIPC) on reperfusion injury have been investigated before, yielding conflicting results. Aim: To assess the impact of a single episode of RIPC on myocardial injury after elective PCI. Material and methods: One hundred and four patients undergoing elective PCI, with normal baseline cardiac troponin-I (cTn-I) values, were randomized to two groups. Two patients were excluded due to data loss, and 102 patients were analyzed. Five minutes of ischemic preconditioning was delivered just before the intervention to the preconditioning group, by inflating the blood pressure cuff up to 200 mm Hg on the non-dominant arm. Postprocedural 16th hour cTn-I, Delta cTn-I (difference between the 16th h and baseline cTn-I values) and the prevalence of type 4a myocardial infarction were compared between the two groups. Results: Median cTn-I values after the procedure were compared. 16th hour cTn-I was insignificantly lower in the preconditioning arm (0.026 mu g/l vs. 0.045 mu g/l, p = 0.186). The incidence of cTn-I elevation 5-fold above the upper reference limit (URL) (> 0.115 mu g/l) was lower in the preconditioning group, but it was also not significant (21.6% vs. 11.8%, p = 0.184). Conclusions: A single episode of RIPC before elective PCI demonstrated less troponin elevation but failed to show a significant effect.
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    Statins decrease mean platelet volume irrespective of cholesterol lowering effect
    (Via Medica, 2013) Sivri, Nasir; Tekin, Gulacan; Yalta, Kenan; Aksoy, Yuksel; Senen, Kubilay; Yetkin, Ertan
    Background: Recent clinical observations have demonstrated that the beneficial effects of statins are not limited to LDL lowering effect. They have also favourable effects on platelet activation, endothelial function, inflammation, and coagulation cascade. Aim: To investigate the effects of statins on mean platelet volume (MPV) which is a simple measure of platelet activation volume in patients who have been prescribed statins. Atorvastatin and rosuvastatin were also compared in respect to effects on MPV. Methods: One hundred and forty five patients were retrospectively included in the study from the outpatient cardiology clinic. Patients who had been given statin treatment were recruited based on the records. Baseline and 4-8 weeks biochemical analysis and haematological measurements and cardiovascular risk factors were recorded. Results: Both statins significantly decreased the MPV. MPV of patients did not show any significant correlation with lipid parameters. Linear regression analysis revealed that there were no statistically significant associations of D MPV with the Delta LDL-cholesterol (beta coefficient = 0.13; p = 0.24), Delta HDL-cholesterol (beta coefficient = 0.17; p = 0.18) or Delta triglyceride (beta coefficient = -0.11; p = 0.21) after statin treatment. Both statins had comparable effects on lipid parameters at the end of the one month follow up period. Conclusion: Statins significantly reduce MPV irrespective of cholesterol levels, and atorvastatin and rosuvastatin have comparable effects in this regard.