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Öğe The comparison of single-dose ceftriaxone, five-day azithromycin, and ten-day amoxicillin/clavulanate for the treatment of children with acute otitis media(Turkish J Pediatrics, 2007) Biner, Betuel; Celtik, Coskun; Oner, Naci; Kucukugurluoglu, Yasemin; Guzel, Ahmet; Yildirim, Cetin; Adali, Mustafa KemalThe aim of the study was to evaluate the efficacy of short-course antimicrobial therapies [single intramuscular dose of ceftriaxone (50 mg/kg, not exceeding 1 g), 5 days of azithromycin (10 mg/kg on day 1, then 5 mg/kg daily on days 2-5) and the traditional 10-day course of amoxicillin/clavulanate (90/6.4 mg/kg/day in 2 doses)] in children with acute otitis media (AOM). The study was conducted as a prospective, comparative, open randomized trial between February 2001 and April 2003, and 104 children were enrolled, with a mean age of 3.8 (2.3) years. The clinical and otoscopic assessments of the children were made on days 0, 3, 11 and 30 after admission, and tympanometry was performed on day 30. The patients were diagnosed and followed with a scoring system. Clinical success was achieved in 29/34 patients (85.3%) in the ceftriaxone group, 27/31 patients (87.1%) in the azithromycin group and 34/39 children (87.2%) in the arnoxicillin/clavulanate group. The rate of persistence of middle-ear fluid did not differ between the three groups (p>0.05). During the one-month period, no recurrent case was observed. The most common drug-related adverse effects were associated with the gastrointestinal system. In conclusion, for the treatment of children with AOM, the clinical success of single-dose intramuscular ceftriaxone and of five-day azithromycin treatments was comparable to that of the traditional 10-day therapy with high-dose arnoxicillin/clavulanate.Öğe Evaluation of Surgical and Histopathologic Results of Patients Operated for Parotid Gland Tumor(Aves Yayincilik, Ibrahim Kara, 2009) Tas, Abdullah; Giran, Safiye; Yagiz, Recep; Yalcin, Oemer; Koten, Muhsin; Adali, Mustafa Kemal; Karasalihoglu, AhmetObjectives: To investigate the patients with parotid tumors retrospectively and to evaluate the surgical procedure, histopathologic results, incidence, follow-up time and complications. Patients and Methods: The study included 56 patients (38 males, 18 females; mean age 52.7 years; range 7 to 86 years) who presented with a mass below or in front of the ear between January 2000 and May 2008. The data regarding patient age, sex, surgical procedure, postoperative histopathologic results and follow-up time were recorded. Results: One of the male patients underwent operation twice because of the bilateral parotid mass. According to the postoperative histopathologic results, 37 of the cases were benign (64.9%), and 20 of them were malign (35.1%). Pleomorphic adenoma (13 patients) and Whartin tumor (13 patients) incidence were similar. Partial superficial parotidectomy, superficial parotidectomy, and total parotidectomy were performed. In addition, some of the patients underwent neck dissection. The most frequent complication was transient facial nerve paresis. Conclusion: For the management of benign parotid gland tumors, superficial or partial superficial parotidectomy is a sufficient surgery. For malign tumors, superficial or total parotidectomy; in cases with neck masses, neck dissection; and in cases involving the facial nerve, facial nerve resection and reconstruction should be performed. According to the type of tumor, postoperative radiation therapy and chemotherapy should be performed as well.Öğe Frequency of Epstein-Barr virus and human papilloma virus in patients with nasopharyngeal carcinoma(Springer, 2020) Altekin, Ilhan; Tas, Abdullah; Yalcin, Omer; Guven, Selis Gulseven; Aslan, Zulkar; Adali, Mustafa Kemal; Karasalihoglu, Ahmet RifatPurpose Nasopharyngeal cancer is a type of malignancy originating from the epithelial cells lining the nasopharynx. In genetic and environmental factors, infection with Epstein-Barr virus is one of the particular factors held accountable for the etiopathogenesis. Human papillomavirus has been associated with cervical, anogenital, and oropharyngeal cancers. The aim of the present study is to demonstrate the presence and incidence of Epstein-Barr virus and human papillomavirus in patients with nasopharyngeal cancer. Methods The information collected for these patients included age at the time of biopsy, gender, alcohol consumption and smoking, and histopathological type of nasopharyngeal cancer. Only patients for whom nasopharyngeal biopsy was performed as punch biopsy were included in the study. In situ hybridization was performed with formalin-fixed, paraffin-embedded tissue sections for Human Papillomavirus and Epstein-Barr virus nucleic acids obtained by means of automated Ventana BenchMark Medical system Results Utilizing in situ hybridization with samples obtained from 56 patients diagnosed with nasopharyngeal cancer. Epstein-Barr virus was positive in 41 out of the 56 (73.2%) patients, while human papillomavirus was positive in 3 (5.4%), and 1 patient (1.8%) had co-infection. Thirty seven (90.2%) of the 41 patients positive for Epstein-Barr virus were Type-2 according to WHO, while 4 (9.8%) were Type-1. All three patients (100%) with Human Papillomavirus positivity were Type-2 according to WHO. Conclusions This study shows the close association between nasopharyngeal cancer and Epstein-Barr virus whereas such an association is not shown for Human Papillomavirus.Öğe Intracranial Complications of Chronic Suppurative Otitis Media(Ekin Tibbi Yayincilik Ltd Sti-Ekin Medical Publ, 2008) Yagiz, Recep; Adali, Mustafa Kemal; Tas, Abdullah; Uzun, Cem; Koten, Muhsin; Karasalihoglu, AhmetObjectives: To evaluate the clinical signs and symptoms, diagnosis-treatments, distributions and outcomes of patients with intracranial complications due to chronic suppurative otitis media (CSOM). Patients and Methods: Data of 42 patients (27 males, 15 gemales; mean age 31.3 years; range 9 to 74 years) diagnosed as intracranial complication due to CSOM were reviewed retrospectively. Patients were investigated on the basis of age, sex, symptoms, findings of otoscopic examination, complications, radiological evaluations, methods of management and findings at the operation. Results: Complications occurred predominantly in patients between 31 and 40 years of age (33.3%). Severe headache, nausea-vomiting, otalgia, purulent otorrhea and fever were the most common signs and symptoms. Meningitis was the most common (115 patients, 35.7%), brain abscess (14 patients, 33.3%) and lateral sinus thrombosis (10 patients, 23.8%) were second and third common complications. The overall mortality rate was 2.4% (in one patient who was comatose on admission), whereas it was 7.1% for patients with brain abscess. Conclusion: Intracranial complications of CSOM are still a serious problem due to life-threatening condition. If a patient with active CSOM has severe headache, nausea-vomiting, otalgia and fever, otogenic intracranial complication should be considered, and detailed evaluation should be performed for early diagnosis since the level of consciousness on admission is an important prognostic factor.Öğe Kikuchi-Fujimoto disease coexisted with Sjogren's syndrome(Springer, 2007) Soy, Mehmet; Peynirci, Hande; Bilgi, Selcuk; Adali, Mustafa Kemal; Guresci, ServetHere we described a case of primary Sjogren's syndrome that coexisted with Kikuchi-Fujimoto disease.Öğe Objective acoustic and aerodynamic analyses of voice after frontal anterior laryngectomy with epiglottoplasty(Aves, 2020) Koder, Ahmet; Karasalihoglu, Ahmet Rifat; Adali, Mustafa Kemal; Koten, Muhsin; Uzun, Cem; Yagiz, Recep; Tas, AbdullahObjective: !n this study, we aimed to pe:form an objective analysis of the acoustic and aerodynamic characteristics of vc.lice dunng the pteGpeiative peUod and the ea:ly and late postopetative pr'' r, at110
