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    The Reasons of Elevated Serum Transaminases in Childhood
    (Turkish Biochem Soc, 2008) Celtik, Coskun; Erbas, Hakan; Kursun, Oemer Serhat; Bostancioglu, Musa; Inan, Mustafa; Oner, Naci; Acunas, Betuel Ayse
    Purpose: To determine the reasons of high serum serum transaminases levels and show the differences according to age and aetiology. Method: During the three years period, 250 cases with elevated serum transaminase levels among the children who hospitalized with various reasons were included to this study. The aetiological factors which caused high serum transaminase levels were classified according to the age groups (newborn, infants and older children). The mean serum transaminase levels were also determined according to aetiological factors. Results: In newborn period, most of the hipertransaminasemia causes were idiopathic. The most frequent pathological causes were perinatal asphyxia, haemolytic diseases and non-hepatitis infections, respectively. The most frequent causes of hipertransaminasemia were drug usage and non-hepatic infections in infancy period, while infectious hepatitis and drug usage were in older children. Among all of the groups, maximum transaminase levels were observed in the patients with infectious hepatitis. Interestingly, in some cases with abdominal blunt trauma, hypertransaminasemia were determined without hepatic injury. Conclusion: The ages and enzyme levels are important for the differential diagnosis of hipertransaminasemia and it should be taken into consideration that high serum transaminase levels could be obtained, even direct hepatic damage had not been observed.