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Öğe Cervical Meningocele in a Newborn: a Case Report(Trakya Üniversitesi, 2020) Şenödeyici, Eylül; Akıncı, Ahmet Tolgay; Aktürk, YenerAims: Neural tube defects are among the most common congenital anomalies worldwide, with a wide range of subtypes. The aim of this case report is to present a patient with cervical meningocele, a rare type of neural tube defect. Case Report: A 33-year-old pregnant woman with a story of bearing an anencephalic baby was referred to Trakya University Hospital with a probable cystic hygroma diagnosis on the 31st week of pregnancy. An antenatal ultrasound revealed a protrusion on the posterior cervical regi- on. Two days before the planned delivery, fetal magnetic resonance imaging was performed by the decision of the council. The 61 x 37 millimeters cyst was planned to be removed upon birth. On the 38th week, the baby was delivered by cesarean section with no other complications. After a preoperative magnetic resonance imaging, surgical procedure including the excision of the cyst and the duroplasty was performed. Conclusion: A rare and devastating congenital anomaly, cervical meningocele, requires accurate diagnosis and prompt surgical involvement for effective treatment and good prognosis.Öğe The Investigation of Medical Student Journals(Trakya Üniversitesi, 2021) Akay, Fatih Erkan; Koçyiğit, Beliz; Tan, Berfin; Yüksel, Ceren; Şenödeyici, Eylül; Çalışkan, Elif; Özdemir, JansetAims: The aim of our study is to examine and evaluate data of medical student journals from around the world for the year 2020. Methods: In this observational study 20 medical student journals were examined. Data analyzed comprised of the year of foundation, country of origin, number of issues per year, types of articles published, and the total number of articles published in a year. Issues that were published in 2020 only were taken into consideration. Results: In 2020, the majority of medical student journals were based in the United States of America, followed by Canada. There were only four indexed (Scopus, Science Citation Index Expanded, PubMed) medical student journals; three were from the United States of America, and one from Canada. In comparison with other journals, the Yale Journal of Biology and Medicine had the most published issues. They also have the most crowded editorial board. Overall, the median of people on the editorial boards and advisory boards were 17.5 and 14, respectively. The median for issues per year was 2. The median number of publications in medical student journals in 2020 was 23. Among them, 13.1% were original research articles, 10.8% review articles, 9.4% case reports, 4.9% editorials, and 2.9% letters to the editor. The remaining 59.0% were publications that fell into the "others" category. Conclusion: In conclusion, the majority of medical student journals are based in North America and Europe, and a substantial amount of the published articles falls into the “others” category. Considering the lack of effective guidance and regulations with relevance to indexing. Medical student journals face certain challenges regarding visibility, accessibility, and publishing articles. However, provided that the editors of medical student journals remain keen, motivated, and focused, medical student journals will contribute to the scientific community by creating a supportive and intellectual environment for aspiring researchers where they can enhance their understanding of scientific research and publishing skills.Öğe Length of Hospital Stays of Patients Operated Due to Glioma Tumours in Neurosurgery Clinics and Intensive Care Units(Trakya Üniversitesi, 2021) Özyiğit, Irmak; Akay, Fatih Erkan; Cengiz, Elif; Özdemir, Janset; Tuncer, Pınar; Şenödeyici, Eylül; Kızılkaya, SarperAims: To evaluate the relationship between the length of hospital stay and age, gender, and disease characteristics among glioma patients who went under surgery in Trakya University School of Medicine. Methods: The data of 51 glioma patients over 18 years of age, who have been followed up during 2019-2020 in Trakya University School of Medicine, Department of Neurosurgery were analyzed. Patients' data comprised of sex, age, tumour location, grades of the tu- mours, the presence of isocitrate dehydrogenase mutation, whether the patients were hospitalized in the intensive care unit or the neurosurgery clinic, duration of hospitalization, and whether radiotherapy and chemotherapy was received. Length of hospital stay was evaluated separately as intensive care unit and the neurosurgery clinic. Results: Out of 51 patients diagnosed with glioma, 18 (35.3%) were female, and 33 (64.7%) were male. The length of neurosurgery clinic and intensive care unit stays were not associated with radiotherapy and chemotherapy approaches. There was a statistically significant difference between the male and female patients in terms of the number of days stayed in the neurosurgery clinic. Conclusion: In conclusion, gender affected the length of neurosurgery clinic stays with a longer duration for female patients in our clinic. A waste number of parameters, including social ones, affect hospital stays. To reveal predictors of postoperative hospitalization thoroughly and overcome the study’s limitations, further prospective studies with larger sample sizes are needed.Öğe Main Genome Editing Tools: An Overview of the Literature, Future Applications and Ethical Questions(Trakya Üniversitesi, 2021) Şenödeyici, Eylül; Şahintürk, Dengiz Koray; Akbolat, Bilge Rana; Dindar, Arzu; Sefer, Selin; Anğay, Gül Feride; Demir, SelmaThe popularity of genome editing technologies in the scientific community has been on the rise for several years. These technologies are slowly becoming a ray of hope for many patients with genetic diseases, thanks to their immense potential for clinical application. New genome editing tools are being rap- idly developed and introduced, while pre-existing ones are being perfected. In the process beginning with the completion of the Human Genome Project to the first clinical trials focusing on cancer immunotherapy and treating blindness, studies on genome editing have increased exponentially. The clustered regularly interspaced short palindromic repeats system is a Nobel Prize-winning genome editing tool celebrated by many researchers and is often praised due to its ease of use, low cost, and efficiency compared to other acknowledged genome editing tools. This review aims to discuss the historical development, working mechanisms, present and future clinical applications of zinc-finger nucleases, transcription activator-like effector nucleases, clustered regularly inter- spaced short palindromic repeats, and prime editors, while presenting the ethical aspects of using these genome editing tools. Keywords: Zinc-finger nucleases, transcription activator-like effector nucleases, clustered regularly interspaced short palindromic repeats, gene editing
